|Related Categories||Abbott, Acetylcholinesterase, Analytical and Industrial Enzymes, Antagonists, Approved Therapeutics/Drug Candidates,|
|color||white to tan|
|solubility||H2O: ≥48 mg/mL|
Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.
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BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions
Inhibitory effects of KW-5092, a novel gastroprokinetic agent, on the activity of acetylcholinesterase in guinea pig ileum. Kishibayashi N, Ishii A, and Karasawa A Jpn. J. Pharmacol. 66(4), 397-403, (1994)
A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Iwanaga Y, Miyashita N, Morikawa K, et al. Gastroenterology 99(2), 401-8, (1990)
Stimulatory effect of N-[4-[2-(dimethylamino)-ethoxy] benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803) on normal and delayed gastrointestinal propulsion. Iwanaga Y, Miyashita N, Mizutani F, et al. Jpn. J. Pharmacol. 56(3), 261-9, (1991)
Simultaneous determination of a new gastrointestinal prokinetic agent (HSR-803) and its metabolites in human serum and urine by high-performance liquid chromatography using automated column-switching. Takahara E, Fukuoka H, Takagi T, et al. J. Chromatogr. A 576(1), 174-8, (1992)
Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: Comparison with cisapride, itopride and mosapride. Matsunaga Y., et al. J. Pharmacol. Exp. Ther. 336, 791-800, (2011)
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