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SML0033 Sigma

Itopride hydrochloride

≥98% (HPLC)

Synonym: N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride, N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride

  • CAS Number 122892-31-3

  • Empirical Formula (Hill Notation) C20H26N2O4 ·HCl

  • Molecular Weight 394.89

  •  MDL number MFCD00881710

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Description

Biochem/physiol Actions

Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antihypertensive Agents

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: Comparison with cisapride, itopride and mosapride. Matsunaga Y., et al. J. Pharmacol. Exp. Ther. 336, 791-800, (2011)

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Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro. Lim, H.C., et al. Yonsei Med. J. 49, 472-478, (2008)

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Stimulatory action of itopride hydrochloride on colonic motor activity in vitro and in vivo. Tsubouchi T., et al. J. Pharmacol. Exp. Ther. 306, 787-793, (2003)

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[Effect of HSR-803 on gastrointestinal motility]. Iwanaga H, Miyashita N, Kondo Y, et al. Nihon Heikatsukin Gakkai Zasshi 25(6), 313-5, (1989)

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A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Iwanaga Y, Miyashita N, Morikawa K, et al. Gastroenterology 99(2), 401-8, (1990)

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Stimulatory effect of N-[4-[2-(dimethylamino)-ethoxy] benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803) on normal and delayed gastrointestinal propulsion. Iwanaga Y, Miyashita N, Mizutani F, et al. Jpn. J. Pharmacol. 56(3), 261-9, (1991)

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Inhibitory effects of KW-5092, a novel gastroprokinetic agent, on the activity of acetylcholinesterase in guinea pig ileum. Kishibayashi N, Ishii A, and Karasawa A Jpn. J. Pharmacol. 66(4), 397-403, (1994)

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Simultaneous determination of a new gastrointestinal prokinetic agent (HSR-803) and its metabolites in human serum and urine by high-performance liquid chromatography using automated column-switching. Takahara E, Fukuoka H, Takagi T, et al. J. Chromatogr. A 576(1), 174-8, (1992)

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Stimulatory effects of HSR-803 on ileal motor activity. Iwanaga Y, Suzuki N, Kato K, et al. Jpn. J. Pharmacol. 62(4), 395-401, (1993)

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