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SML0060 Sigma

NB001

≥98% (HPLC)

Synonym: 5-[[2-(6-Amino-9H-purin-9-yl)ethyl]amino]-1-pentanol; HTS 09836

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Properties

Related Categories Adenylyl Cyclase Activators, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   CVPTTZZCRDVGSU-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   H2O: ≥24 mg/mL
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Application

NB001 may be used in adenylyl cyclase 1-mediated cell signaling studies.

Biochem/physiol Actions

NB001, originally believed to be a selective inhibitor of adenylyl cyclase 1 (AC1), new evidence suggests NB001 does not interact with AC1 directly. NB001 may reduce cAMP accumulation in cells through an unknown mechanism that is dependent on AC1.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers
15

References

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