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SML0208 Sigma

KYP-2047

≥95% (HPLC)

Synonym: (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,
InChI Key   SPXFAUXQZWJGCJ-ROUUACIJSA-N
assay   ≥95% (HPLC)
form   oil
storage condition   desiccated
color   white to light brown
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Application

KYP-2047 may be used in prolyl endopeptidase-mediated cell signaling studies.

Biochem/physiol Actions

KYP-2047 clears the α-synuclein aggregates induced by oxidative stress in the neuronal cells. α-synuclein is the main component of Lewy bodies in Parkinson′s disease that cause neuronal cell death and dementia.

KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 has been found to be neuroprotective against glutamate and oxygen, glucose deprivation in vitro. It has also been used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Neuropeptidases

The term "neuropeptidases" refers to those enzymes that participate in the inactivation of synaptically released neuropeptides and therefore serve to turn off the generated peptide signal. In general...
Keywords: AGE, Alzheimer Disease, Angiogenesis, Anti-inflammatory agents, Cancer, Cardiovascular, Cell proliferation, Degradations, Diabetes, Digestions, Gene expression, Hormones, Inflammation, Metabolism, Neurotransmitters, Normal-phase chromatography, Obesity, Respiratory, Schizophrenia, Sequencing

Peer-Reviewed Papers
15

References

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