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SML0256 Sigma

2OHOA

≥98% (HPLC)

Synonym: (9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid, 2-Hydroxy Oleic Acid, Minerval

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Properties

Related Categories 0-9, Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   JBSOOFITVPOOSY-KTKRTIGZSA-N
assay   ≥98% (HPLC)
storage condition   protect from light
color   white to tan
solubility   DMSO: >20 mg/mL
storage temp.   room temp

Description

Biochem/physiol Actions

2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

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Flow Cytometry Instruments
Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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