|Related Categories||Antioxidants and Cytoprotectants, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress More...|
|optical activity||[α]/D -8 to -15°, c = 1 in H2O|
|color||white to beige|
|solubility||H2O: >10 mg/mL|
S-allyl-L-cysteine is a sulfur containing amino acid found in garlic with antioxidant, anti-cancer, antihepatotoxic, neuroprotective and neurotrophic activity. S-allyl-L-cysteine has potent activity in several animal models of ischemic injury and Alzhemer′s disease.
Effect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats. Saravanan G, Ponmurugan P, and Begum MS J. Trace Elem. Med. Biol. 27(2), 143-7, (2013)
S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Tobón-Velasco JC, Vázquez-Victorio G, Macías-Silva M, et al. Free Radic. Biol. Med. 53(5), 1024-40, (2012)
The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Colín-González AL, Santana RA, Silva-Islas CA, et al. Oxid. Med. Cell. Longev. 2012, 907162, (2012)
Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. Saravanan G and Ponmurugan P J. Diabetes Complications 26(4), 280-5, (2012)
S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead. Mandal S, Mukherjee S, Chowdhury KD, et al. Biochim. Biophys. Acta 1820(1), 9-23, (2012)
The "aged garlic extract:" (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD). Ray B, Chauhan NB, Lahiri DK. Curr. Med. Chem. 18, 3306-3313, (2011)
S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Javed H, Khan MM, Khan A, et al. Brain Res. 1389, 133-42, (2011)
Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Saravanan G and Ponmurugan P Exp. Toxicol. Pathol. 64(6), 639-44, (2012)
S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice. Rojas P, Serrano-García N, Medina-Campos ON, et al. J. Nutr. Biochem. 22(10), 937-44, (2011)
Palladium(II) complex with S-allyl-L-cysteine: new solid-state NMR spectroscopic measurements, molecular modeling and antibacterial assays. Spera MB, Quintão FA, Ferraresi DK, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(1), 313-8, (2011)
Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. Ray, B., et al. J. Neurochem. 117, 388-402, (2011)
s-Allyl cysteine, s-ethyl cysteine, and s-propyl cysteine alleviate β-amyloid, glycative, and oxidative injury in brain of mice treated by D-galactose. Tsai, S.J., et al. J. Agric. Food Chem. 59, 6319-6326, (2011)
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