SML0337 Sigma


≥98% (HPLC)

Synonym: L-Deoxyalliin, S-allyl-cysteine, S-allylcysteine, SAC

  • CAS Number 21593-77-1

  • Empirical Formula (Hill Notation) C6H11NO2S

  • Molecular Weight 161.22

  •  MDL number MFCD00151975

  •  eCl@ss 32160406



Related Categories A-AM, Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -8 to -15°, c = 1 in H2O
color   white to beige
solubility   H2O: >10 mg/mL
storage temp.   2-8°C


Biochem/physiol Actions

S-allyl-L-cysteine is a sulfur containing amino acid found in garlic with antioxidant, anti-cancer, antihepatotoxic, neuroprotective and neurotrophic activity. S-allyl-L-cysteine has potent activity in several animal models of ischemic injury and Alzhemer′s disease.

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Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
WGK Germany 


Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers


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S-allyl cysteine mitigates oxidative damage and improves neurologic deficit in a rat model of focal cerebral ischemia. Ashafaq, M., et al. Nutr. Res. 32, 133-143, (2012)


s-Allyl cysteine, s-ethyl cysteine, and s-propyl cysteine alleviate β-amyloid, glycative, and oxidative injury in brain of mice treated by D-galactose. Tsai, S.J., et al. J. Agric. Food Chem. 59, 6319-6326, (2011)


Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. Ray, B., et al. J. Neurochem. 117, 388-402, (2011)


Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. Ried K, Frank OR, and Stocks NP Eur. J. Clin. Nutr. 67(1), 64-70, (2013)


[Effect of S-allyl-L-cysteine on isolate heart subject to ischemia/reperfusion]. Xue M, Cui J, Xia W, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi 27(1), 13-7, (2011)


S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Tobón-Velasco JC, Vázquez-Victorio G, Macías-Silva M, et al. Free Radic. Biol. Med. 53(5), 1024-40, (2012)


Nuclear factor κB-dependent anti-inflammatory effects of s-allyl cysteine and s-propyl cysteine in kidney of diabetic mice. Mong MC and Yin MC J. Agric. Food Chem. 60(12), 3158-65, (2012)


The "aged garlic extract:" (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD). Ray B, Chauhan NB, Lahiri DK. Curr. Med. Chem. 18, 3306-3313, (2011)


A garlic derivative, S-allylcysteine (SAC), suppresses proliferation and metastasis of hepatocellular carcinoma. Ng KT, Guo DY, Cheng Q, et al. PLoS ONE 7(2), e31655, (2012)


S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice. Rojas P, Serrano-García N, Medina-Campos ON, et al. J. Nutr. Biochem. 22(10), 937-44, (2011)


Palladium(II) complex with S-allyl-L-cysteine: new solid-state NMR spectroscopic measurements, molecular modeling and antibacterial assays. Spera MB, Quintão FA, Ferraresi DK, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(1), 313-8, (2011)


Effects of SAC on oxidative stress and NO availability in placenta: potential benefits to preeclampsia. Yu J, Feng L, Hu Y, et al. Placenta 33(6), 487-94, (2012)


The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Colín-González AL, Santana RA, Silva-Islas CA, et al. Oxid. Med. Cell. Longev. 2012, 907162, (2012)


S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Javed H, Khan MM, Khan A, et al. Brain Res. 1389, 133-42, (2011)


Role of allyl group in the hydroxyl and peroxyl radical scavenging activity of S-allylcysteine. Maldonado PD, Alvarez-Idaboy JR, Aguilar-González A, et al. J. Phys. Chem. B 115(45), 13408-17, (2011)


Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Saravanan G and Ponmurugan P Exp. Toxicol. Pathol. 64(6), 639-44, (2012)


S-Allylcysteine inhibits tumour progression and the epithelial-mesenchymal transition in a mouse xenograft model of oral cancer. Pai MH, Kuo YH, Chiang EP, et al. Br. J. Nutr. 108(1), 28-38, (2012)


S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead. Mandal S, Mukherjee S, Chowdhury KD, et al. Biochim. Biophys. Acta 1820(1), 9-23, (2012)


Effects of s-allyl-L-cysteine on cell proliferation and neuroblast differentiation in the mouse dentate gyrus. Nam SM, Yoo DY, Kim W, et al. J. Vet. Med. Sci. 73, 1071-1075, (2011)


The effects and underlying mechanisms of S-allyl l-cysteine treatment of the retina after ischemia/reperfusion. Chen YQ, Pan WH, Liu JH, et al. J. Ocul. Pharmacol. Ther. 28(2), 110-7, (2012)


High temperature- and high pressure-processed garlic improves lipid profiles in rats fed high cholesterol diets. Sohn CW, Kim H, You BR, et al. J. Med. Food 15(5), 435-40, (2012)


S-allylcysteine induces cell cycle arrest and apoptosis in androgen-independent human prostate cancer cells. Liu Z, Li M, Chen K, et al. Mol. Med. Report. 5(2), 439-43, (2012)


Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma. Sengupta D, Chowdhury KD, Sarkar A, et al. Biochim. Biophys. Acta 1840(1), 219-44, (2014)


S-Allylcysteine, a garlic compound, increases ABCA1 expression in human THP-1 macrophages. Malekpour-Dehkordi Z, Javadi E, Doosti M, et al. Phytother Res. 27(3), 357-61, (2013)


Effect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats. Saravanan G, Ponmurugan P, and Begum MS J. Trace Elem. Med. Biol. 27(2), 143-7, (2013)


Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. Saravanan G and Ponmurugan P J. Diabetes Complications 26(4), 280-5, (2012)


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