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SML0341 Sigma

Importazole

≥98% (HPLC)

Synonym: N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine

  • CAS Number 662163-81-7

  • Empirical Formula (Hill Notation) C20H22N4

  • Molecular Weight 318.42

  •  MDL number MFCD04077630

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
InChI Key   HKGJEZIGDHFJFL-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: >5 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.

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Certificate of Analysis

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Peer-Reviewed Papers
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