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SML0341 Sigma

Importazole

≥98% (HPLC)

Synonym: N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine

  • CAS Number 662163-81-7

  • Empirical Formula (Hill Notation) C20H22N4

  • Molecular Weight 318.42

  •  MDL number MFCD04077630

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Description

Biochem/physiol Actions

Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.

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Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β. Soderhom, J.F., et al. ACS Chem. Biol. Apr. 21, (2011)

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane. Kotak S, Busso C, and Gönczy P EMBO J. 33(16), 1815-30, (2014)

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