|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics More...|
|color||white to beige|
|solubility||DMSO: soluble10 mg/mL at warmed, clear|
|shipped in||wet ice|
Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences.
Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor. Rani SG, Mohan SK, and Yu C Biochemistry 49(11), 2585-92, (2010)
Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract. Burgess JA, van der Ven PF, Martin M, et al. J. Contemp. Dent. Pract. 9(3), 88-98, (2008)
An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial. Liu J, Zeng X, Chen Q, et al. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 102(4), 475-81, (2006)
Voltage-dependent N-type Ca2+ channel activity regulates the interaction between FGF-1 and S100A13 for stress-induced non-vesicular release. Matsunaga H and Ueda H Cell. Mol. Neurobiol. 26(3), 237-46, (2006)
Inhibitory effects of amlexanox on carbachol-induced contractions of rabbit ciliary muscle and guinea-pig taenia caecum. Watanabe N, Tominaga Y, Mizutani K, et al. J. Pharm. Pharmacol. 52(11), 1377-85, (2000)
Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study. Fu J, Zhu X, Dan H, et al. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 113(5), 638-43, (2012)
A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. Meng W, Dong Y, Liu J, et al. Trials 10, 30, (2009)
Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein. Okada M, Tokumitsu H, Kubota Y, et al. Biochem. Biophys. Res. Commun. 292(4), 1023-30, (2002)
Neuron-specific non-classical release of prothymosin alpha, a novel neuroprotective DAMPs. Halder, S.K., et al. J. Neurochem. Jul 31, (2012)
Synergistic Ca2+ and Cu2+ requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance: an initial step in amlexanox-reversible non-classical release of FGF1. Matsunaga, H., and Ueda, H. Neurochem. Int. 52, 1076-1085, (2008)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?