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SML0603 Sigma

Lixivaptan

≥96% (HPLC)

Synonym: N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide, VPA 985, WAY-VPA 985

  • CAS Number 168079-32-1

  • Empirical Formula (Hill Notation) C27H21ClFN3O2

  • Molecular Weight 473.93

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
description   4% w/w in ethyl acetate
assay   ≥96% (HPLC)
form   powder
color   white
solubility   DMSO: soluble20 mg/mL, clear
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Vasopressin and Oxytocin Receptors

The pituitary hormones arginine vasopressin (AVP) and oxytocin (OT) are structurally related cyclic nonapeptides that act as hormones and neurotransmitters. Both peptides are synthesized in neurons i...
Keywords: Atomic absorption spectroscopy, Cardiovascular, Diabetes, Gene expression, Hormones, Ligands, Neurotransmitters, Transduction

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