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SML0714 Sigma

FSLLRY-NH2 trifluoroacetate salt

≥98% (HPLC)

  • CAS Number 245329-02-6 (free base)

  • Empirical Formula (Hill Notation) C39H60N10O8 · xC2HF3O2

  • Molecular Weight 796.96 (free base basis)

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Blood, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to off-white
shipped in   wet ice
storage temp.   −20°C

Description

Amino Acid Sequence

Phe-Ser-Leu-Leu-Arg-Tyr-NH2 trifluoroacetate salt

Packaging

1 mg in glass bottle

Biochem/physiol Actions

FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assays, the peptide inhibits agonist-induced cardiocyte remodeling, and production of cytokines by endothelial cells.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Proteinase-Activated Receptors

The search for a functional thrombin receptor, using expression cloning methods, led to the discovery of a G protein-coupled receptor that mediates the actions of thrombin on platelets and endothelia...
Keywords: Atomic absorption spectroscopy, Cancer, Cloning, Gastrointestinal, Gene expression, Inflammation, Ligands, Physiological Processes, Rearrangements, Transduction

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