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SML0899 Sigma

Windorphen

≥98% (HPLC)

Synonym: (Z)-3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde

  • CAS Number 19881-70-0

  • Empirical Formula (Hill Notation) C17H15ClO3

  • Molecular Weight 302.75

Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   white to beige
solubility   DMSO: soluble5 mg/mL, clear (warmed)
shipped in   wet ice
storage temp.   −20°C

Description

Other Notes

Light sensitive

Biochem/physiol Actions

Windorphen is a selective Wnt/β-catenin signaling inhibitor acting through selective inhibition of p300, a histone acetyltransferase (HAT) that also acts as a critical coactivator of β-catenin, a transcription factor that mediates the Wnt signaling pathway involved in embryogenesis and cancer cell survival. Windorphen blocks Wnt signaling by selectively disrupting the association of p300 with the C-terminal transactivation domain of β-catenin-1. Windorphen does not inhibit the closely related CREB-binding protein (CBP). Windorphen induced apoptosis in several Wnt-dependent tumor cell lines including colon adenocarcinoma SW480and RKO and prostate cancer cell lines DU145 and PC3.

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