EMAIL THIS PAGE TO A FRIEND
SML0992 Sigma

Bromosporine

≥98% (HPLC)

Synonym: N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate

  • Empirical Formula (Hill Notation) C17H20N6O4S

  • Molecular Weight 404.44

  •  MDL number MFCD26142669

  •  PubChem Substance ID 329825627

Purchase

Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   UYBRROMMFMPJAN-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white
solubility   DMSO: soluble20 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Bromodomains (BRDs) are protein-interaction modules that "read" ε-N-lysine acetylation motifs, such as those found in the N-terminal tails of histones. BRDs have been identified in chromatin-modifying enzymes (such as histone acetyltransferases (HATs)) as well as in transcription factors that regulate genes for cell cycle progression, signal transduction, apoptosis, and inflammation. Proteins containing bromodomains have been implicated in various diseases, such as cancers, inflammatory diseases and neurological diseases. Bromosporine is a broad spectrum BRD inhibitor. In HeLa cells, bromosporine accelerates FRAP recovery of BRD4 and CREBBP at 1μM. For full characterization details, please visit the Bromosporine probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

Bromosporine is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Price and Availability


Better Together

Discover your Target

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, Post translational modifications, Transcription

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Comments

Add to Cart

SML1279 LLY-507, ≥97% (HPLC)
SML1276 BAZ2-ICR, ≥98% (HPLC)
PZ0307 PFI-4, ≥98% (HPLC)
SML1408 (R)-PFI-2, ≥97% (HPLC)
SML1410 A-366, ≥98% (HPLC) SGC epigenetic chemical probe
SML1486 NI-57, ≥98% (HPLC)
PZ0312 (S)-PFI-2 SGC epigenetic chemical probe
SML1534 I-BRD9, ≥98% (HPLC)
U4885 UNC0638 hydrate, ≥98% (HPLC) SGC epigenetic chemical probe
SML0067 IOX1, ≥97% (HPLC) SGC epigenetic chemical probe
SML0352 PFI-1, ≥98% (HPLC) SGC epigenetic chemical probe
SML0652 IOX2, ≥98% (HPLC) SGC epigenetic chemical probe
SML0662 UNC1215, ≥98% (HPLC)
SML0701 GSK-J4, ≥98% (HPLC) SGC epigenetic chemical probe
SML0709 GSK-J1, ≥98% (HPLC) SGC epigenetic chemical probe
SML0768 GSK2801, ≥98% (HPLC) SGC epigenetic chemical probe
SML0766 GSK343, ≥98% (HPLC)
SML0778 UNC1999, ≥98% (HPLC)
SML0974 (+/-)-JQ1, ≥98% (HPLC) SGC epigenetic chemical probe
SML0939 PFI-3, ≥98% (HPLC) SGC epigenetic chemical probe
SML1037 UNC0642, ≥98% (HPLC)
SML1072 GSK-LSD1, ≥98% (HPLC) SGC epigenetic chemical probe
SML1107 SGC0946, ≥98% (HPLC)
SML1133 SGC-CBP30, ≥98% (HPLC) SGC epigenetic chemical probe
SML1134 I-CBP112, ≥98% (HPLC) SGC epigenetic chemical probe
SML1184 OF-1, ≥98% (HPLC) SGC epigenetic chemical probe
SML1209 OICR-9429, ≥98% (HPLC)
SML1242 SGC707, ≥98% (HPLC)

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?