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SML1375 Sigma

Galeterone

≥98% (HPLC)

Synonym: 3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene, TOK-001, VN-124-1, VN/124-1

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Properties

Related Categories Androgen, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Drug and Xenobiotic Metabolism,
InChI Key   PAFKTGFSEFKSQG-PAASFTFBSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL clear
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Galeterone is an inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17-α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Galeterone, moreover, is a potent blocker of the androgen receptor and causes down-regulation of androgen receptor (AR) protein expression in vitro and in vivo.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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