SML1482

Ogerin

≥98% (HPLC)

• Synonym(s): 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-benzenemethanol, [2-[4-Amino-6-(benzylamino)-1,3,5-triazin-2-yl]phenyl]methanol
• Empirical Formula (Hill Notation): C₁₇H₁₇N₅O
• CAS Number: 1309198-71-7
• Molecular Weight: 307.35
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825911
• NACRES: NA.77

Properties

• Product Name: Ogerin, ≥98% (HPLC)
• SMILES string: OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1
• InChI: 1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
• InChI key: MDGIEDNDSFMSLP-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100

Description

Application

Ogerin has been used in G-protein-coupled receptors (GPCR) deorphanization[1] and phosphatidylinositol hydrolysis assay.[2]

Biochem/physiol Actions

Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1).

Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.

Other Notes

Ogerin negative control, a structurally similar analog of ogerin, is available from Sigma. To learn more about and purchase ogerin negative control, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable