• USA Home
  • SRP0134 - EZH2/EED/SUZ12/RbAp48/AEBP2 human

SRP0134 Sigma

EZH2/EED/SUZ12/RbAp48/AEBP2 human

recombinant, expressed in baculovirus infected insect cells

Synonym: ENX-1, EZH2, Enhancer of zeste homolog 2, KMT6A, Lysine N-methyltransferase 6A



Related Categories Epigenetics, Histone Modifying Enzymes, Methyltransferases, Molecular Biology, Proteins and Peptides for Epigenetic Research More...
recombinant   expressed in baculovirus infected insect cells
form   aqueous solution
mol wt   mol wt 48 kDa (RbAp48)
  mol wt 51 kDa (EED)
  mol wt 53 kDa (AEBP2)
  mol wt 86 kDa (EZH2)
  mol wt 87 kDa (SUZ12)
NCBI accession no.   NM_003797 (EED)
  NM_003797 (EED)
  NM_004456 (EZH2)
  NM_005610 (RbAP48)
  NM_015355 (SUZ12)
  NM_153207 (AEBP2)
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... EZH2(2146)


Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Unit Definition

One unit is defined as the amount of enzyme required to methylate 1 pmol of substrate/min at 37°C.

Physical form

Formulated in 25 mM Tris-HCl, pH 8.0, 138 mM NaCl, 0.05% Tween-20 and 10% glycerol.


EZH2/EED/SUZ12/RbAp48/AEBP2 human is useful for the study of enzyme kinetics, screening inhibitors and selectivity profiling.

General description

EZH2, EED, SUZ12, RbAp48 and AEBP2 are components of the polycomb repressive complex 2 (PRC2). The highly conserved complex methylates lysine 27 of histone H3. It also has a role in gene silencing and transcription repression.

Price and Availability

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Protocols & Articles


Modulators and Proteins for Methylation

DNA methyltransferases are a family of enzymes that catalyze the transfer of a methyl group to DNA. There are five related DNA cytosine-5-methyltransferases (DNMTs) that transfer a methyl group from ...
Savita Bagga, PhD.
BioFiles v7 n3, 2012, 7–9
Keywords: Gene expression, Methylations, PAGE

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?