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SRP0293 Sigma

Cathepsin V Active human

recombinant, expressed in FreeStyle 293-F cells, ≥90% (SDS-PAGE)

Synonym: Cathepsin L2, Cathepsin U

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Properties

Related Categories Apoptosis and Cell Cycle, Cathepsins and Granzymes, Cathepsins and Granzymes Enzymes, Cell Biology, Cell Signaling and Neuroscience More...
recombinant   expressed in FreeStyle 293-F cells
assay   ≥90% (SDS-PAGE)
form   aqueous solution
mol wt   mol wt 37 kDa
NCBI accession no.   NM_001333.2
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CTSL2(1515)

Description

General description

Human cathepsin V (GenBank Accession No. NM_001333.2), CD33 signal peptide(amino acids 1-16) + cathepsin V (amino acids 18-334), with C-terminal HIS tag, MW = 37 kDa, expressed in FreeStyle 293-F cells.

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Unit Definition

One unit is defined as the amount of enzyme that will cleave 1 pmol of substrate per min at 37°C

Physical form

Formulated in 40 mM MES, pH 5.0, 120 mM NaCL and 20% glycerol.

Application

Active human cathepsin V is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human cathepsin V has been used in a study to assess the cysteine protease attribute of the eukaryotic ribosomal protein S4. Active human cathepsin V has also been used in a study to determine that the simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.

Legal Information

FreeStyle is a trademark of Invitrogen Corp.

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NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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