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SRP0294 Sigma

FAP Active human

recombinant, expressed in baculovirus, ≥50% (SDS-PAGE)

Synonym: FAPA, Fibroblast activation protein, α, Melanoma membrane-bound gelatinase 170 kDa, Seprase

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Properties

recombinant   expressed in baculovirus
assay   ≥50% (SDS-PAGE)
form   aqueous solution
mol wt   mol wt 85.5 kDa
NCBI accession no.   NM_004460
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... FAP(2191)

Description

General description

Human FAP (GenBank Accession No. NM_004460), (amino acids 29-end) with C-terminal HIS tag, MW = 85.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Unit Definition

One unit is defined as the amount of enzyme that will cleave 1 pmol of substrate per min at 37°C

Physical form

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol and 3 mM DTT.

Application

Active human FAP is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human FAP has been used in a study to assess the role of FAP48 in HIV-associated lipodystrophy. Active human FAP has also been used in a study to investigate the current state of domino transplantation in surgical procedures and de novo amyloid neuropathy.

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Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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