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T0203 Sigma

TGFβR2 (190-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: AAT3, FAA3, HPNCC6, MFS2, RIIC, TAAD2, TGFR-2

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   6-8 nmol/min·mg
mol wt   mol wt ~68 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... TGFBR2(7048)

Description

Biochem/physiol Actions

TGFbR2 is a member of the TGFb receptor subfamily and is a ser/thr protein kinase. TGFbR2-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses. The TGFbR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-beta type II receptor. Mutations in TGFbR2 gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

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Protocols & Articles
Peer-Reviewed Papers
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