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T0256 Sigma

Trypsin inhibitor from bovine pancreas

Type I-P, essentially salt-free, lyophilized powder

Synonym: BPTI

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Properties

Related Categories A to C, Biochemicals and Reagents, Chymotrypsin, α-, Chymotrypsin, alpha-, Enzyme Inhibitors,
type   Type I-P
form   essentially salt-free, lyophilized powder
mol wt   mol wt ~6500 Da (single-chain 58-amino acid peptide)
purified by   crystallization
storage temp.   −20°C

Description

Analysis Note

One mg of trypsin inhibitor will inhibit greater than 1.5 mg of trypsin with activity of approximately 10,000 BAEE units per mg protein.

Protein determined by biuret.

Other Notes

View more information on Trypsin Inhibitor.

Packaging

1, 5, 10, 25 mg in glass bottle

Preparation Note

Prepared by method of Kunitz and Northrup, J. Gen. Physiol., 19, 991 (1936).

Unit Definition

One trypsin unit will produce a ΔA253 of 0.001 per min with BAEE as substrate at pH 7.6 at 25 °C; reaction volume 3.2 ml, 1 cm light path.

Biochem/physiol Actions

A 58-residue protein whose binding to various serine proteases has been extensively studied. It is highly homologous to a family of mamba snake dendrotoxin proteins that inhibit various K+ channels. It also binds to an intracellular site associated with the large conductance Ca2+-activated K+ channel..

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Protocols

Enzymatic Assay of Trypsin Inhibitor

This procedure applies to all products that have a specification for Trypsin Inhibition at Sigma-Aldrich, St. Louis.

Peer-Reviewed Papers
15

References

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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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