|Related Categories||Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|color||white to beige|
|solubility||DMSO: >10 mg/mL|
|Gene Information||human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)|
The effect of Tranilast on mast cell surface receptors was studied in murine bone marrow-derived mast cells.1
Tranilast is an anti-asthma drug, which inhibits LTC4 and PGE2 formation in stimulated monocytes, but does not inhibit cyclooxygenase or lipoxygenase activity; inhibits mast cell degranulation; inhibits VEGF-induced angiogenesis in vivo and also inhibits proliferation and tube formation of human endothelial cells in vitro. Tranilast may represent a new class of drugs for therapy to treat ongoing TH1-mediated autoimmune diseases.
Certificate of Analysis
A pilot study of scheduled endoscopic balloon dilation with oral agent tranilast to improve the efficacy of stricture dilation after endoscopic submucosal dissection of the esophagus. Uno K, Iijima K, Koike T, et al. J. Clin. Gastroenterol. 46(9), e76-82, (2012)
Biocompatibility and antifibrotic effect of UV-cross-linked hyaluronate as a release-system for tranilast after trabeculectomy in a rabbit model--a pilot study. Spitzer MS, Sat M, Schramm C, et al. Curr. Eye Res. 37(6), 463-70, (2012)
Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability. Onoue S, Kojo Y, Aoki Y, et al. Drug Metab. Pharmacokinet. 27(4), 379-87, (2012)
Case in which tranilast ophthalmic solution was thought to be effective for the prevention of symblepharon and recurrence after pterygium surgery. Tsuji A, Kawai K, Fan H, et al. Tokai J. Exp. Clin. Med. 36(4), 120-3, (2011)
Suppression of human CD4+ T cell activation by 3,4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10. Hertenstein A, Schumacher T, Litzenburger U, et al. Biochem. Pharmacol. 82(6), 632-41, (2011)
Production of tranilast [N-(3',4'-dimethoxycinnamoyl)-anthranilic acid] and its analogs in yeast Saccharomyces cerevisiae. Eudes A, Baidoo EE, Yang F, et al. Appl. Microbiol. Biotechnol. 89(4), 989-1000, (2011)
Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction. Nakatani Y, Nishida K, Sakabe M, et al. J. Am. Coll. Cardiol. 61(5), 582-8, (2013)
Suppression of the allogeneic response by the anti-allergy drug N-(3,4-dimethoxycinnamonyl) anthranilic acid results from T-cell cycle arrest. Zaher SS, Coe D, Chai JG, et al. Immunology 138(2), 157-64, (2013)
Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation. Glinka Y, Mohammed N, Subramaniam V, et al. Biochem. Biophys. Res. Commun. 425(4), 775-80, (2012)
Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor β/Smad pathways. Tao Y, Hu L, Li S, et al. Transplant. Proc. 43(5), 1985-8, (2011)
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