• USA Home
  • T0442 - Anti-phospho-Tyk2 (pTyr1054/1055) antibody produced in rabbit

EMAIL THIS PAGE TO A FRIEND
T0442 Sigma

Anti-phospho-Tyk2 (pTyr1054/1055) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Purchase

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Phosphoproteins at Phosphotyrosine (pTyr),
species reactivity   human
application(s)   western blot: 1:1000
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
mol wt   mol wt 134 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TYK2(7297)
biological source   rabbit
conjugate   unconjugated
UniProt accession no.   P29597

Description

Immunogen

synthetic phospho-Tyr1054/1055 peptide corresponding to residues around Tyr1054/1055 of human Tyk2.

General description

Tyk2 is a member of the Jak family of protein tyrosine kinases. It associates with and is activated by
receptors for many cytokines including IL-13, the IL-6 family, IL-10, and IFN-a and β. Following ligand binding,
Tyk2 is activated by phosphorylation of Tyr1054 and/or Tyr1055. Tyk2 is required for the tyrosine phosphoryla-
tion of Stat3 in the IFN-β signaling cascade.

Physical form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

Specificity

Detects human Tyk2 only when phosphorylated at Tyr1054/1055.

Price and Availability


Antibody Explorer

Explore with Confidence
Safety & Documentation

Safety Information

WGK Germany  2
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?