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  • T0442 - Anti-phospho-Tyk2 (pTyr1054/1055) antibody produced in rabbit

T0442 Sigma

Anti-phospho-Tyk2 (pTyr1054/1055) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution


Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Phosphoproteins at Phosphotyrosine (pTyr),
species reactivity   human
application(s)   immunoprecipitation: 1:250
  western blot (chemiluminescent): 1:1,000 using interferon-α-treated Hela cell extract
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TYK2(7297)
biological source   rabbit
conjugate   unconjugated



synthetic phospho-Tyr1054/1055 peptide corresponding to residues around Tyr1054/1055 of human Tyk2.

General description

Tyk2 is the first member of Jak family of non-receptor protein tyrosine kinases that was identified to be essential for cytokine signalling. Tyk2 is associated with the interferon-γreceptor and upon ligand binding it is activated by phosphorylation on Tyr1054 and/or Tyr1055. Tyk2 along with Jak2 is necessary for IFN-γ signalling and for differentiation of naïve Th cells to IFN-γ-producing Th1 cells. Tyk2 also regulates Toll-like receptor 9 signalling in the dendritic cells, though the mechanism is not very clear.
Anti-phospho-Tyk2 (phosphotyrosine 1054/1055) detects Tyk2 only when phosphorylated at phosphotyrosine 1054/1055.

Physical form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol


Detects human Tyk2 only when phosphorylated at Tyr1054/1055.


Anti-phospho-Tyk2 (pTyr1054/1055) antibody may be used at a working dilution of 1:1000 for detection by immunoblotting in IFN-γ-treated HeLa cell lysate. It may be used for immunoprecipitation at a working dilution of 1:250.

Price and Availability

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