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T0557 Sigma

Sodium taurodeoxycholate hydrate

BioXtra, ≥97% (TLC)

Synonym: 2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate

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Properties

Related Categories Anionic Detergents, Bile Salts, Biochemicals and Reagents, Cell Culture, Detergents,
description   anionic
InChI Key   OLPIZAYYAVQETM-GGPRKOIFSA-M
product line   BioXtra
assay   ≥97% (TLC)
mol wt   micellar avg mol wt 3100
aggregation number   6
impurities   ≤0.002% Phosphorus (P)
  ≤0.1% Insoluble matter
CMC   1-4 mM(20-25°C)
mp   168 °C (dec.)(lit.)
solubility   H2O: 0.5 M clear, colorless to faintly yellow
anion traces   chloride (Cl-): ≤0.5%
  sulfate (SO42-): ≤0.05%
cation traces   Al: ≤0.0005%
  Ca: ≤0.005%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.01%
  Mg: ≤0.005%
  NH4+: ≤0.05%
  Pb: ≤0.001%
  Zn: ≤0.0005%

Description

Application

Bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins.

Sodium tauroursodeoxycholate has been used in a study to assess short-term feedback regulation of bile salt uptake in rodent liver. It has also been used in a study to investigate its potential to resolve endoplasmic reticulum (ER) stress in intestinal epithelial cells. It is also used for isolation of membrane proteins including inner mitochondrial membrane proteins.

General description

Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.

Packaging

1, 5 g in poly bottle

500 mg in poly bottle

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Bile Acids

The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine. Bile acids...
BioFiles 2007, 2.7, 17.
Keywords: Absorption, Digestions, Transcription

Bile Salts and Bile Salt Hydrolase

Several Lactobacillus and Bifidobacterium probiotic strains exhibit bile salt hydrolase (BSH) activity and are suspected to play a role in combating the negative effects of bile via detoxification of...
Chloe McClanahan
Biofiles Edition 6.2
Keywords: Detoxification, Probiotics, Thin layer chromatography, Titrations

LC/MS Analysis of Conjugated Bile Acids on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Conjugated Bile Acids on Ascentis® Express C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

Probiotics and Human Health

At the beginning of the 20th century, probiotics were thought to have a beneficial effect to the host by improving the intestinal microbial balance. Through his studies and observations, the Russian ...
Chloe McClanahan
BioFiles Edition 6.2
Keywords: AGE, Absorption, Adhesion, Amplification, Anaerobic, Antimicrobials, Apoptosis, Cancer, Capillary electrophoresis, Carcinogens, Cell culture, Cell proliferation, Chromatography, Coagulation, Detoxification, Diagnostic, Diseases, Enzyme activity, Fermentation, Gas chromatography, Gastrointestinal, Genomics, High performance liquid chromatography, Immunology, Inflammation, Magnetic resonance spectroscopy, Metabolism, Metabolites, Microbiology, Molecular biology, Nucleic acid hybridization, Pharmaceutical, Phosphorylations, Polymerase chain reaction, Polymerase chain reaction - quantitative, Prebiotics, Probiotics, Reductions, Respiratory, Sequencing, Thin layer chromatography, Titrations

Peer-Reviewed Papers
15

References

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