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T0678 Sigma

Monoclonal Anti-Tryptophan Hydroxylase antibody produced in mouse

clone WH-3, ascites fluid

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Neurobiology, Antibodies for Neurotransmission, Antibodies for Neurotransmitter Synthesis and Metabolism,
species reactivity   rabbit, rat, human, monkey
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
  microarray: suitable
  western blot: 1:1,000 using rabbit pineal gland extract
clone   WH-3, monoclonal
antibody form   ascites fluid
isotype   IgG3
mol wt   antigen mol wt 55 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TPH1(7166), TPH2(121278)
rat ... Tph1(24848), Tph2(317675)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant rabbit tryptophan hydroxylase.

General description

The tryptophan hydroxylase 1 gene (TPH1) is a 444 amino acid protein encoded by the gene spanning 29 kbp with11 exons on human chromosome 11p15.3-p14. The enzyme is expressed in the gut, spleen, thymus, pituitary and also in the pineal gland.

Specificity

This antibody reacts specifically with tryptophan hydroxylase.

Application

Monoclonal Anti-Tryptophan Hydroxylase antibody produced in mouse has been used in immunohistochemistry and immunoblotting.

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  nwg
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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