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T1014 Sigma

TNPAL-Sphingomyelin

1 mg/mL in chloroform/methanol (2:1)

Synonym: Trinitrophenylaminolauroylsphingomyelin

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Description

Packaging

1, 5 mg in serum bottle

Substrates

Substrate for microbial and animal sphingomyelinases.

Application

TNPAL-Sphingomyelin was used as substrate to determine the activity of sphingomyelinase spectrophotometrically.

Biochem/physiol Actions

Sphingomyelin (SM) is a sphingolipid found in the myelin sheath and cell membranes of animals. The regulation of SM content by sphingomyelinase and SM synthase 2 affect the membrane properties and signaling. Excess oxysterols result in increased amount of SM and calcium ions that is the main reason for artery blockage and atherosclerosis.

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Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
RIDADR 
UN 1992 6.1(3) / PGII
WGK Germany 
3
Flash Point(F) 
51.8 °F
Flash Point(C) 
11 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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