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T103 Sigma

Trifluperidol hydrochloride

Synonym: 4′-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m tolyl)piperidino]butyrophenone hydrochloride, R 2498, Triperidol

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Properties

Related Categories Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
InChI Key   VYGQXRZAHIZHQV-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   white to off-white
solubility   DMSO: ≥20 mg/mL
  H2O: soluble
  ethanol: moderately soluble
Gene Information   human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Application

The interaction of Trifluperidol hydrochloride with NMDA receptors was studied in rat brain buffy coat membranes.

Biochem/physiol Actions

Trifluperidol is a dopamine receptor antagonist with antipsychotic effects used in the treatment of schizophrenia. This neuroleptic penetrates the brain and also affects the glial cells leading to increased release of proinflammatory cytokines. It also alters the metabolism of carbohydrates and amino acids in the brain cortex.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
EU3550000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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