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T104 Sigma

Tropisetron monohydrochloride

solid, ≥98% (HPLC)

Synonym: 1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride, 3-Tropanylindole-3-carboxylate monohydrochloride, ICS-205,930, Navoban

  • CAS Number 105826-92-4

  • Empirical Formula (Hill Notation) C17H20N2O2 · HCl

  • Molecular Weight 320.81

  •  MDL number MFCD00210221

  •  PubChem Substance ID 24278133

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Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
InChI Key   XIEGSJAEZIGKSA-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
solubility   H2O: >10 mg/mL
originator   Novartis
storage temp.   2-8°C
Gene Information   human ... CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
rat ... Chrna7(25302), Drd2(24318), Htr1a(24473), Htr3a(79246)

Description

Biochem/physiol Actions

3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT3 serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

Packaging

50 mg in poly bottle

Application

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
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Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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