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T123 Sigma

Thioperamide maleate salt

solid

Synonym: MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt

  • CAS Number 148440-81-7

  • Empirical Formula (Hill Notation) C15H24N4S · C4H4O4

  • Molecular Weight 408.52

  •  MDL number MFCD00083209

  •  PubChem Substance ID 24277809

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Properties

Related Categories Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
InChI Key   REZRBLGMJZZSID-BTJKTKAUSA-N
assay   ≥98% (HPLC)
form   solid
storage condition   desiccated
  under inert gas
color   white
solubility   H2O: >10 mg/mL
  DMSO: soluble12 mg/mL
  ethanol: soluble3 mg/mL
Gene Information   human ... HRH3(11255)

Description

Packaging

10, 25, 100 mg in poly bottle

Application

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


Neuroscience Grant Programm
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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