(±)-Thalidomide

Papers

Thalidomide is an inhibitor of angiogenesis. D’Amato, et al. Proc. Natl. Acad. Sci. U. S. A. 91, 4082, (1994)

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Thalidomide inhibits the replication of human immunodeficiency virus type 1. Makonkawkeyoon, et al. Proc. Natl. Acad. Sci. U. S. A. 90, 5974-5878, (1993)

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Inhibitors of NF-kappaB derived from thalidomide. de-Blanco E.J., et al. Bioorg. Med. Chem. Lett. 17, 6031-5, (2007)

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Tubulin-polymerization inhibitors derived from thalidomide. Shunsuke Inatsuki et al Bioorg. Med. Chem. Lett. 15, 321-5, (2005)

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Cell differentiation inducers derived from thalidomide. Tomomi Noguchi et al Bioorg. Med. Chem. Lett. 15, 3212-5, (2005)

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Angiogenesis inhibitors derived from thalidomide. Tomomi Noguchi et al Bioorg. Med. Chem. Lett. 15, 5509-13, (2005)

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Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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Synthesis and TNF expression inhibitory properties of new thalidomide analogues derived via Heck cross coupling. Scott G Stewart et al Bioorg. Med. Chem. Lett. 17, 5819-24, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Arumugam Kodimuthali et al J. Med. Chem. 51, 5471-89, (2008)

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Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton. Aya Nakagawa et al Bioorg. Med. Chem. 16, 7046-54, (2008)

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Development and biological evaluation of C(60) fulleropyrrolidine-thalidomide dyad as a new anti-inflammation agent. Sheng-Tung Huang et al Bioorg. Med. Chem. 16, 8619-26, (2008)

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Design, synthesis and antitumor evaluation of novel thalidomide dithiocarbamate and dithioate analogs against Ehrlich ascites carcinoma-induced solid tumor in Swiss albino mice. Magdy A-H Zahran et al Bioorg. Med. Chem. 16, 9708-18, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides. Takeshi Yamamoto et al Bioorg. Med. Chem. Lett. 19, 3973-6, (2009)

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Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. Fabien Vincent et al Bioorg. Med. Chem. Lett. 19, 6793-6, (2009)

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Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application. Christiane Contino-Pépin et al Bioorg. Med. Chem. Lett. 19, 878-81, (2009)

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Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-alpha production. Miguel Fernández Braña et al Eur. J. Med. Chem. 44, 3533-42, (2009)

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Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates. Yolanda Karla Cupertino da Silva et al Bioorg. Med. Chem. 18, 5007-15, (2010)

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New thalidomide analogues derived through Sonogashira or Suzuki reactions and their TNF expression inhibition profiles. Scott G Stewart et al Bioorg. Med. Chem. 18, 650-62, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Stable and orally bio-available pro-drugs of CPS11. Aihong Huo et al Bioorg. Med. Chem. Lett. 21, 6242-4, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives. Paola Hernández et al Bioorg. Med. Chem. 20, 2158-71, (2012)

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Merck 14,9255