|Related Categories||Angiogenesis, Angiogenesis Inhibitors, Angiogenesis Regulators, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,|
|solubility||DMSO: soluble20 mg/mL, clear|
human ... LITAF(9516), TNF(7124)|
mouse ... Nos2(18126)
rat ... Nos1(24598)
Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.
Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology1. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells2.
(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma3.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T144.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
|Precautionary statements||P280-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||46-61-21-25-62|
|Safety Statements (Europe)||53-22-26-36/37/39-45|
|RIDADR||UN 2811 6.1 / PGIII|
1. Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease. He P, Cheng X, Staufenbiel M, et al. PLoS ONE 8(2), e55091, (2013)
Design, synthesis and antitumor evaluation of novel thalidomide dithiocarbamate and dithioate analogs against Ehrlich ascites carcinoma-induced solid tumor in Swiss albino mice. Magdy A-H Zahran et al Bioorg. Med. Chem. 16, 9708-18, (2008)
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. Fabien Vincent et al Bioorg. Med. Chem. Lett. 19, 6793-6, (2009)
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates. Yolanda Karla Cupertino da Silva et al Bioorg. Med. Chem. 18, 5007-15, (2010)
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