Synonym: 17β-Hydroxy-3-oxo-4-androstene, 17β-Hydroxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one, trans-Testosterone
|Related Categories||Androgen, Androgen Modulators, Application Index, Bioactive Small Molecules, Biochemicals and Reagents,|
|drug control||USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada|
45% (w/v) aq 2-hydroxypropyl-β-cyclode|
|absolute ethanol: soluble0.5 mg/ml|
|chloroform: soluble100 mg/mL, clear, colorless to very faintly yellow|
|methyl oleate: slightly soluble|
|vegetable oils: soluble|
human ... AR(367), EBP(10682), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)|
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)
Live Chat and Frequently Asked Questions are available for this Product.
Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.
Testosterone dissolves in chloroform at 100 mg/ml to yield a clear, colorless to very faint yellow solution. It is also soluble in methanol, absolute ethanol (0.5 mg/ml), 45 percent (w/v) aqueous 2-hydroxypropyl-b-cyclode
Testosterone has been used as a standard to study the developmental profile of steroid hormones in male and female rat brains1. This hormone has also been used to evaluate its effects on muscle mass and signaling in mice2.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P201-P281-P308 + P313|
|Personal Protective Equipment||Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||45-63|
|Safety Statements (Europe)||53-36/37-45|
Intracellular receptors (IRs) are a class of ligand-dependent transcription factors that include receptors for both steroid and non-steroid hormones. Upon binding their cognate hormone, these recepto...
Keywords: Anti-inflammatory agents, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell proliferation, Diseases, Diuretics, Gene expression, Hormones, Infrared spectroscopy, Ligands, Metabolism, Metabolites, Transcription, Transduction
1. Developmental Time Course Of Estradiol, Testosterone, And Dihydrotestosterone Levels In Discrete Regions Of Male And Female Rat Brain. Konkle, A.T., and McCarthy, M.M. Endocrinology 152, 223-35, (2011)
2. Voluntary Running, Skeletal Muscle Gene Expression, And Signaling Inversely Regulated By Orchidectomy And Testosterone Replacement. Ibebunjo, C., et al. Am. J. Physiol. Endocrinol. Metab. 300, E327-40, (2011)
Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4.
. Lu, P., et al. Drug Metab. Dispos. 29(11), 1473-1479, (2001)
Rosenfield, R. L. Adv. Pediatrics 19, 172, (1972)
Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. Wang G, Weng CC, Shao SH, et al. J. Androl. 30(3), 338-48, (2009)
[Hormonal-metabolic pattern of postmenopausal females with new onset of diabetes mellitus type 2: the role of cancer and hereditary predisposition to diabetes]. Bershteĭn LM, Vasil'ev DA, Poroshina TE, et al. Vestn. Ross. Akad. Med. Nauk (2), 29-34, (2013)
Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors. Anagnostopoulou V, Pediaditakis I, Alkahtani S, et al. Endocrinology 154(7), 2446-56, (2013)
Relationship between serum levels of testosterone, zinc and selenium in infertile males attending fertility clinic in Nnewi, south east Nigeria. Oluboyo AO, Adijeh RU, Onyenekwe CC, et al. Afr. J. Med. Med. Sci. 41 Suppl, 51-4, (2012)
Regulation of luteinizing hormone receptor in hippocampal neurons following different long-lasting treatments of castrated adult rats. Abtahi H, Shabani M, Jameie SB, et al. Indian J. Exp. Biol. 51(3), 218-27, (2013)
Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Mitkov MD, Aleksandrova IY, and Orbetzova MM Folia Med. (Plovdiv.) 55(1), 55-63, (2013)
[Specifics of hormonal and energy balance in patients with hyperplasia and endometrial neoplasia with metabolic syndrome in the background]. Chernyshova AL, Kolomiets LA, Bochkarëva NV, et al. Vopr. Onkol. 59(1), 65-71, (2013)
Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels. Kvorning T, Christensen LL, Madsen K, et al. J. Am. Geriatr. Soc. 61(6), 957-62, (2013)
Foetal exposure to Panax ginseng extract reverts the effects of prenatal dexamethasone in the synthesis of testosterone by Leydig cells of the adult rat. Wanderley MI, Saraiva KL, César Vieira JS, et al. Int. J. Exp. Pathol. 94(3), 230-40, (2013)
Of mice and men--warning: intact versus castrated adult male mice as xenograft hosts are equivalent to hypogonadal versus abiraterone treated aging human males, respectively. Michiel Sedelaar JP, Dalrymple SS, and Isaacs JT Prostate 73(12), 1316-25, (2013)
Comparison of effects of the rise in serum testosterone by raloxifene and oral testosterone on serum insulin-like growth factor-1 and insulin-like growth factor binding protein-3. Duschek EJ, Gooren LJ, and Netelenbos C Maturitas 51(3), 286-93, (2005)
Short vs. long rest period between the sets in hypertrophic resistance training: influence on muscle strength, size, and hormonal adaptations in trained men. Ahtiainen JP, Pakarinen A, Alen M, et al. J. Strength Cond. Res. 19(3), 572-82, (2005)
Estrogen synthesis in the central nucleus of the amygdala following middle cerebral artery occlusion: role in modulating neurotransmission. Saleh TM, Connell BJ, Legge C, et al. Neuroscience 135(4), 1141-53, (2005)
Steroid hormones and steroid hormone binding globulins in cerebrospinal fluid studied in individuals with intact and with disturbed blood-cerebrospinal fluid barrier. Schwarz S and Pohl P Neuroendocrinology 55(2), 174-82, (1992)
The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women. Schaap LA, Pluijm SM, Smit JH, et al. Clin. Endocrinol. (Oxf.) 63(2), 152-60, (2005)
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. Bhasin S, Cunningham GR, Hayes FJ, et al. J. Clin. Endocrinol. Metab. 91(6), 1995-2010, (2006)
Serum testosterone: A potentially adjunct screening test for the assessment of the risk of prostate cancer among men with modestly elevated PSA values (> or =3.0 and <10.0 ng/ml). Karamanolakis D, Lambou T, Bogdanos J, et al. Anticancer Res. 26(4B), 3159-66, (2006)
Testosterone levels among men with spinal cord injury: relationship between time since injury and laboratory values. Clark MJ, Schopp LH, Mazurek MO, et al. Am. J. Phys. Med. Rehabil. 87(9), 758-67, (2008)
Profiling neurosteroids in cerebrospinal fluids and plasma by gas chromatography/electron capture negative chemical ionization mass spectrometry. Kim YS, Zhang H, and Kim HY Anal. Biochem. 277(2), 187-95, (2000)
Adrenal and gonadal contributions to urinary excretion and plasma concentration of epitestosterone in men--effect of adrenal stimulation and implications for detection of testosterone abuse. Kicman AT, Coutts SB, Cowan DA, et al. Clin. Endocrinol. (Oxf.) 50(5), 661-8, (1999)
Pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomy. Imamoto T, Suzuki H, Fukasawa S, et al. Eur. Urol. 47(3), 308-12, (2005)
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