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T151 Sigma

(+)-Thalidomide

≥98% (HPLC), powder

Synonym: R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

  • CAS Number 2614-06-4

  • Empirical Formula (Hill Notation) C13H10N2O4

  • Molecular Weight 258.23

  •  MDL number MFCD00210220

  •  PubChem Substance ID 24899975

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Properties

Related Categories Angiogenesis Regulators, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   UEJJHQNACJXSKW-SECBINFHSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: soluble15 mg/mL, clear
originator   Celgene
storage temp.   room temp
Gene Information   human ... LITAF(9516), TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)

Description

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

Packaging

10, 100 mg in glass bottle

Preparation Note

Thalidomide is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml. It is insoluble in ethanol and water.

Application

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.

Features and Benefits

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TI4925000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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