(+)-α-Tocopherol

Papers

Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant Lu, J., et al. Bioorg. Med. Chem. 18, 7628-38, (2010)

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Design, synthesis, and evaluation of pharmacological properties of cinnamic derivatives as antiatherogenic agents. Caroline Lapeyre et al J. Med. Chem. 48, 8115-24, (2005)

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2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity. Young-Sik Jung et al Bioorg. Med. Chem. Lett. 15, 1125-9, (2005)

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Radical scavenging activity of protein from tentacles of jellyfish Rhopilema esculentum. Huahua Yu et al Bioorg. Med. Chem. Lett. 15, 2659-64, (2005)

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A labdane diterpene glucoside from the rhizomes of Curcuma mangga. Faridah Abas et al J. Nat. Prod. 68, 1090-3, (2005)

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Constituents of Vittaria anguste-elongata and their biological activities. Pei-Lin Wu et al J. Nat. Prod. 68, 1180-4, (2005)

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Antioxidative constituents of Etlingera elatior. Habsah Mohamad et al J. Nat. Prod. 68, 285-8, (2005)

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Antioxidant phenolic glycosides from Moricandia arvensis. Hatem Braham et al J. Nat. Prod. 68, 517-22, (2005)

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Polyhydroxylated 4-thiaflavans as multipotent antioxidants: protective effect on oxidative DNA damage in vitro. Maura Lodovici et al Bioorg. Med. Chem. Lett. 16, 1957-60, (2006)

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Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis. In-Kyoung Lee et al Bioorg. Med. Chem. Lett. 16, 5621-4, (2006)

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Terpenoids and a diarylheptanoid from Zingiber ottensii. Kayo Akiyama et al J. Nat. Prod. 69, 1637-40, (2006)

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Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity. In-Kyoung Lee et al J. Nat. Prod. 69, 299-301, (2006)

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Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. Hyoung Ja Kim et al J. Nat. Prod. 69, 600-3, (2006)

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Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity. Concettina La Motta et al J. Med. Chem. 50, 4917-27, (2007)

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Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes. Sk Ugir Hossain et al Bioorg. Med. Chem. Lett. 17, 1149-54, (2007)

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Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents. Kyoko Nakagawa-Goto et al Bioorg. Med. Chem. Lett. 17, 5204-9, (2007)

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Synthetic tyrosyl gallate derivatives as potent melanin formation inhibitors. Chan Woo Lee et al Bioorg. Med. Chem. Lett. 17, 5462-4, (2007)

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Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. In-Kyoung Lee et al Bioorg. Med. Chem. 15, 3309-14, (2007)

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On the cytotoxicity and status of oxidative stress of two novel synthesized tri-aza macrocyclic diamides as studied in the V79 cell lines. Massod Mashhadi Akbar Boojar et al Bioorg. Med. Chem. 15, 3437-44, (2007)

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Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion. Sothea Kim et al Bioorg. Med. Chem. 15, 3572-8, (2007)

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Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents. D L A Rakotondramanana et al Bioorg. Med. Chem. 15, 6018-26, (2007)

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Second generation of alpha-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization. Gloria V López et al Bioorg. Med. Chem. 15, 6262-72, (2007)

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Diminished ciprofloxacin-induced chondrotoxicity by supplementation with magnesium and vitamin E in immature rats. Kerstin Pfister et al Antimicrob. Agents Chemother. 51, 1022-7, (2007)

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Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. Masahiko Yano et al Antimicrob. Agents Chemother. 51, 2016-27, (2007)

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Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis. Ya-Ching Shen et al J. Nat. Prod. 70, 1139-45, (2007)

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Triterpene, antioxidant, and antimicrobial compounds from Melissa officinalis. Teresa Mencherini et al J. Nat. Prod. 70, 1889-94, (2007)

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Glycosides from the stem bark of Fraxinus sieboldiana. Sheng Lin et al J. Nat. Prod. 70, 817-23, (2007)

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Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E. Hua Huang et al Proc. Natl. Acad. Sci. U. S. A. 104, 18666-70, (2007)

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Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate. Luís Sánchez-del-Campo et al J. Med. Chem. 51, 2018-26, (2008)

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Development of novel antiatherogenic biaryls: design, synthesis, and reactivity. Mélanie Delomenède et al J. Med. Chem. 51, 3171-81, (2008)

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Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents. András Nemes et al J. Med. Chem. 51, 479-86, (2008)

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Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides. Tae-Souk Kang et al Bioorg. Med. Chem. Lett. 18, 1663-7, (2008)

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Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. Keiko Nishio et al Bioorg. Med. Chem. 16, 10332-7, (2008)

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Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Tomohiro Itoh et al Bioorg. Med. Chem. 16, 7592-8, (2008)

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Novel keto-enamine Schiffs bases from 7-hydroxy-4-methyl-2-oxo-2H-benzo[h] chromene-8,10-dicarbaldehyde as potential antidyslipidemic and antioxidant agents. Koneni V Sashidhara et al Eur. J. Med. Chem. 43, 2592-6, (2008)

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QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES. A A Toropov et al Eur. J. Med. Chem. 43, 714-40, (2008)

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Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum. Chien-Chang Wu et al J. Nat. Prod. 71, 1027-31, (2008)

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Total synthesis and cytoprotective properties of dykellic acid. Christina M Thompson et al J. Med. Chem. 52, 117-25, (2009)

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20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity. Jie Liu et al Bioorg. Med. Chem. Lett. 19, 3320-3, (2009)

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Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents. Samir Ghosh et al Bioorg. Med. Chem. Lett. 19, 386-9, (2009)

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N-tert-butyl and N-methyl nitrones derived from aromatic aldehydes inhibit macromolecular permeability increase induced by ischemia/reperfusion in hamsters. Ayres G Dias et al Bioorg. Med. Chem. 17, 3995-8, (2009)

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Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3. Tomohiro Itoh et al Bioorg. Med. Chem. 17, 5374-9, (2009)

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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. Oktay Talaz et al Bioorg. Med. Chem. 17, 6583-9, (2009)

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Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity. Gloria V López et al Bioorg. Med. Chem. 17, 8143-8, (2009)

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Antidyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases. Koneni V Sashidhara et al Eur. J. Med. Chem. 44, 1813-8, (2009)

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Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity. Luke Alvey et al Eur. J. Med. Chem. 44, 2497-505, (2009)

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Sesquiterpenoids and phenylpropanoids from pericarps of Illicium oligandrum. Qin Zhu et al J. Nat. Prod. 72, 238-42, (2009)

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Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta. Abdülselam Erta? et al J. Nat. Prod. 72, 500-2, (2009)

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Synthesis of novel benzocoumarin derivatives as lipid lowering agents. Koneni V Sashidhara et al Bioorg. Med. Chem. Lett. 20, 3065-9, (2010)

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Novel coumarin derivatives as potential antidyslipidemic agents. Koneni V Sashidhara et al Bioorg. Med. Chem. Lett. 20, 4248-51, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents. Nilgün Karali et al Eur. J. Med. Chem. 45, 1068-77, (2010)

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Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity. Maria Koufaki et al Eur. J. Med. Chem. 45, 1107-12, (2010)

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Synthesis and antioxidant properties of enone core based dendrimers with carbazole as surface group. Perumal Rajakumar et al Eur. J. Med. Chem. 45, 1220-4, (2010)

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Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines]. M Veera Narayana Reddy et al Eur. J. Med. Chem. 45, 1828-32, (2010)

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Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine. V Koteswara Rao et al Eur. J. Med. Chem. 45, 203-9, (2010)

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Structure-activity relationship studies of acridones as potential antipsoriatic agents. 1. Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth. Aleksandar Putic et al Eur. J. Med. Chem. 45, 3299-310, (2010)

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Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents. Atul Kumar et al Eur. J. Med. Chem. 45, 501-9, (2010)

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Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum. Yu-Jen Kuo et al J. Nat. Prod. 73, 109-14, (2010)

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An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Yunbao Liu et al J. Nat. Prod. 73, 1193-5, (2010)

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Flavonoids in the poisonous plant Oxytropis falcata. Wen-Hao Chen et al J. Nat. Prod. 73, 1398-403, (2010)

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Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23. Keiichiro Motohashi et al J. Nat. Prod. 73, 226-8, (2010)

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Saponins and polyphenols from Fadogia ancylantha (makoni tea). Teresa Mencherini et al J. Nat. Prod. 73, 247-51, (2010)

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Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles. Ebraheem Abdu Musad et al Bioorg. Med. Chem. Lett. 21, 3536-40, (2011)

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Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids. Koneni V Sashidhara et al Bioorg. Med. Chem. Lett. 21, 4480-4, (2011)

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Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity. T Narender et al Bioorg. Med. Chem. Lett. 21, 6393-7, (2011)

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Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS. Jen-Hao Cheng et al Eur. J. Med. Chem. 46, 1222-31, (2011)

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Naphthoquinone-like Polyketide Isolated from Streptomyces sp. RI-77 and Its Predicted Biosynthetic Pathway. Miho Izumikawa et al J. Nat. Prod. 74, 2588-91, (2011)

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Towards a modern definition of vitamin E-evidence for a quinone hypothesis. William D Shrader et al Bioorg. Med. Chem. Lett. 22, 391-5, (2012)

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Antioxidative oligostilbenes from Caragana sinica. Qinghao Jin et al Bioorg. Med. Chem. Lett. 22, 973-6, (2012)

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Cyclic dipeptides exhibit potency for scavenging radicals. Tadashi Furukawa et al Bioorg. Med. Chem. 20, 2002-9, (2012)

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Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase. Md Maniruzzaman Manir et al Bioorg. Med. Chem. 20, 2376-81, (2012)

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JBIR-94 and JBIR-125, antioxidative phenolic compounds from Streptomyces sp. R56-07. Teppei Kawahara et al J. Nat. Prod. 75, 107-10, (2012)

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Vitamin E: Application of the principles of physical organic chemistry to the exploration of its structure and function. G.W. Burton, K.U. Ingold Acc. Chem. Res. 19, 194, (1986)

Merck 14,9495

Beil. 17,V,4,168

Aldrich MSDS 1, 1840:D / Corp MSDS 1 (2), 3609:B / FT-IR 1 (1), 1103:A / FT-IR 2 (2), 1886:A / FT-NMR 1 (2), 297:B / RegBook 1 (1), 1293:K / Sigma FT-IR 1 (1), 727:A / Structure Index 1, 197:D:8