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T1566 Sigma

Tie-1/Fc Chimera human

≥90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Synonym: Tyrosine kinase with Ig and EGF homology domains 1

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Description

Biochem/physiol Actions

Tie (tyrosine kinase with Ig and EGF homology domains) receptors Tie-1 and Tie-2 are receptor tyrosine kinase (RTK) family members with unique structural characteristics that involve their two Ig-like, three EGF-like and three fibronectin III-like motifs in the extracellular domain. They also have a split tyrosine kinase domain in the cytoplasmic region. They are expressed primarily on endothelial cells and hematopoietic progenitors. Tie-1 and Tie-2 are thought to play critical roles in angiogenesis and hematopoiesis. Tie-1 is related to endothelial cell differentiation and maintenance of endothelium integrity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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