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T1705 Sigma

Anti-TDP-43 antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ALS10, Anti-TARDBP, Anti-TARDP43, Anti-Tar DNA binding protein 43

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Properties

Related Categories ALS, Prion Disease, and Others, ALS, Prion Disease, and others, Alphabetical Index, Antibodies, Antibodies for Neurobiology,
species reactivity   mouse, human, rat
application(s)   immunohistochemistry: 5-10 μg/mL using rat, mouse or human kidney
  indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells
  western blot: 1.5-3.0 μg/mL using human U2OS cell lysates
clone   polyclonal
concentration   ~1.5 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~43 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TARDBP(23435)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 181-198 of human TDP-43, conjugated to KLH. The corresponding sequence is highly conserved (single amino acid substitution) in mouse and rat TDP-43.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-TDP-43 antibody produced in rabbit may be used to tag Tar DNA binding protein 43 (TDP-43, TARDP43, ALS10), a heterogeneous nuclear ribonucleoprotein (hnRNP), for detection and quantitation by Western blotting, immunoblotting or immunofluorescence and in tissue by immunohistochemical (IHC) techniques. Anti-TDP-43 antibody is used as a probe to determine the roles of TDP-43 in the generation and processing of RNA, including transcription, splicing, transport and stability. Anti-TDP-43 antibody may be used in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD-TDP) research.

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WGK Germany  1
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