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T1875 Sigma

Testosterone propionate

solid

Synonym: 17β-Hydroxy-4-androsten-3-one 17-propionate, 17β-Propionyloxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one 17-propionate

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Properties

Related Categories Androgen, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
InChI Key   PDMMFKSKQVNJMI-BLQWBTBKSA-N
form   solid
drug control   USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
color   white
solubility   : soluble1 in 20 of ethyl oleate
  acetone: soluble1 in 4 of acetone
  chloroform: soluble50 mg/ml, clear, colorless to faintly yellow
  ethanol: soluble1 in 6 of ethanol
  ethyl oleate: soluble1 in 20 of ethyl oleate
  propylene glycol: soluble1 in 30 of propylene glycol
  ethanol: soluble10 mg/mL
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble4.4 mg/mL
  H2O: insoluble
  oil: soluble
Gene Information   human ... CYP17A1(1586)
rat ... Ar(24208)

Description

Preparation Note

This product is soluble in chloroform (50 mg/ml). It is also soluble in various oils. The oil solutions can be sterilized by maintaining at 150 deg C for 1 hour. It is practically insoluble in water, soluble 1 in 6 of ethanol, 1 in 4 of acetone, 1 in 20 of ethyl oleate, and 1 in 30 of propylene glycol. The product is incompatible with alkalis and oxidizing agents and it should be protected from light.

Physical form

Photosensitive solid

Application

Testosterone propionate has been used for studying its effects on pregnant ewes,.

Biochem/physiol Actions

Androgens direct the development of the male phenotype during embryogenesis and at puberty. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone in the target tissues where it regulates several biological functions. Testosterone propionate has been synthetically derived from a plant. This product has extended and faster-acting functions when compared to other testosterone esters.

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Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
XA3115000
Protocols & Articles
Peer-Reviewed Papers
15

References

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