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  • T1940 - Anti-Transforming Growth Factor-β Soluble Receptor III antibody produced in goat

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T1940 Sigma

Anti-Transforming Growth Factor-β Soluble Receptor III antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-TGF-β sRIII

Description

Immunogen

recombinant human TGF-β sRIII (betaglycan) expressed in NSO cells

General description

Transforming growth factor-β (TGF-β) belongs to the TGF-β superfamily of secreted proteins. The TGF-β family is involved in a variety of signaling pathways that involve serine/threonine protein kinases. TGF-β acts through binding to three transmembrane receptors in mammals, type I, type II and type III receptors. It is expressed by most cell types and regulates the DNA-binding activity of transcription factors. The important pathways regulated by TGF-β are the SMAD, BMP, MAPK and PI3K/Akt pathways. TGF-β is involved in cell and tissue differentiation, proliferation, morphogenesis, secretion of metalloproteases and inflammation. Deregulation of TGF-β signaling has been implicated in many developmental syndromes and cancer progression
Anti-TGF-β sRIII recognizes the extracellular domain of human TGF-β RIII.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Application

Anti-TGF-β sRIII antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody may be used for indirect ELISA at a concentration of 0.5-1 μg/ml.

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