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T1941 Sigma

Anti-TrkB antibody produced in goat

affinity isolated antibody, lyophilized powder

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Description

Immunogen

recombinant human TrkB extracellular domain expressed in NS0 cells.

General description

The antibody recognizes recombinant human TrkB. It shows no cross-reactivity with TrkC, NT-3, NT-4, BDNF and NGF-β.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing 5% trehalose.

Biochem/physiol Actions

The development and maintenance of central and peripheral nervous system is controlled by a family of Trk family of neurotrophin receptors. The Trk family consists of 3 members, TrkA (NTRK1), Trk B (NTRK2) and TrkC (NTRK3). Neurotrophins have an important role in development of the nervous system and mediate the cellular effects by binding to the Trk receptors. Trk receptors reportedly play a major role in the development and behaviour of neuroblastomas and other type of cancers.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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