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T1941 Sigma

Anti-TrkB antibody produced in goat

affinity isolated antibody, lyophilized powder

Description

Immunogen

recombinant human TrkB extracellular domain expressed in NS0 cells.

General description

The antibody recognizes recombinant human TrkB. It shows no cross-reactivity with TrkC, NT-3, NT-4, BDNF and NGF-β.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing 5% trehalose.

Biochem/physiol Actions

The development and maintenance of central and peripheral nervous system is controlled by a family of Trk family of neurotrophin receptors. The Trk family consists of 3 members, TrkA (NTRK1), Trk B (NTRK2) and TrkC (NTRK3). Neurotrophins have an important role in development of the nervous system and mediate the cellular effects by binding to the Trk receptors. Trk receptors reportedly play a major role in the development and behaviour of neuroblastomas and other type of cancers.

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