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T2067 Sigma

Tyrphostin AG 879

99% (HPLC)

Synonym: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide

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Properties

Related Categories Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Cell Biology,
InChI Key   XRZYELWZLNAXGE-KPKJPENVSA-N
assay   99% (HPLC)
solubility   DMSO: soluble (at 26 mg/ml)
  H2O: insoluble
Gene Information   human ... ERBB2(2064), NTRK1(4914)

Description

Biochem/physiol Actions

Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.

Packaging

5 mg in glass bottle

Preparation Note

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.

Application

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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