T2067 Sigma

Tyrphostin AG 879

99% (HPLC)

Synonym: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide



Related Categories Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Cell Biology,
assay   99% (HPLC)
solubility   DMSO: soluble (at 26 mg/ml)
  H2O: insoluble
Gene Information   human ... ERBB2(2064), NTRK1(4914)


Biochem/physiol Actions

Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.


5 mg in glass bottle

Preparation Note

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.


Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2.

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NONH for all modes of transport
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