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T2379 Sigma

Tubocurarine hydrochloride pentahydrate

≥97%

Synonym: (+)-Tubocurarine hydrochloride

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Properties

Related Categories Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   WMIZITXEJNQAQK-GGDSLZADSA-N
assay   ≥97%
solubility   H2O: soluble50 mg/ml, with heating as required, clear, colorless to yellow
  ethanol: soluble
  methanol: soluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

Muscle relaxant; nicotinic acetylcholine receptor antagonist; can induce neuromuscular paralysis.

Preparation Note

Tubocurarine hydrochloride pentahydrate is soluble in water at 50 mg/ml (with heat as required) and yields a clear to slightly hazy, colorless to yellow solution. It is also soluble in methanol and ethanol.

Application

Tubocurarine has been used as an acetylcholine receptor (AChR)-blocking agent for electromyographic studies in rat models of myasthenia gravis7. It has also been used to inhibit nicotinic AChRs in rats. This study reported that tubocurarine decreased motor axonal regeneration8.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN2 6.1 / PGII
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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