|Related Categories||Bioactive Small Molecules, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Neurobiology,|
|drug control||USDEA Schedule I; Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada|
human ... CNR2(1269)|
mouse ... Cnr1(12801)
rat ... Cnr1(25248)
Δ9-Tetrahydrocannabinol solution is essentially insoluble in water.
Δ9-Tetrahydrocannabinol or Δ9-THC is a psychoactive ingredient in marijuana that is known to function as a neuroprotective antioxidant21. In vivo microdialysis studies have reported that Δ9-THC can enhance extracellular dopamine efflux in the nucleus accumbens of conscious, freely-moving rats22.
Agonist at CB1 and CB2 cannabinoid receptors. Hallucinogen; major psychoactive component of marijuana from Cannabis sativa.
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~1 mg/mL in ethanol, analytical standard, for drug analysis
1.0 mg/mL in methanol, analytical standard, for drug analysis
1.0 mg/mL±5% in methanol, analytical standard, for drug analysis
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|Personal Protective Equipment||Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter|
|Hazard Codes (Europe)||F|
|Risk Statements (Europe)||11|
|Safety Statements (Europe)||16|
|RIDADR||UN 1170C 3 / PGII|
|Flash Point(F)||57.2 °F|
|Flash Point(C)||14 °C|
Cannabinoid receptors derive their name from Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive principle in Cannabis sativa (marijuana). Although marijuana has been in use for over 4,000 years as a ...
Keywords: AGE, Atomic absorption spectroscopy, Endocannabinoids, Gene expression, Infrared spectroscopy, Ligands, Metabolism, Neurotransmitters, Transduction
The transient receptor potential family of ion channels consists of at least 28 mammalian members divided into six subfamilies: 7 TRPC (canonical), 6 TRPV (vanilloid), 8 TRPM (melastatin), 1 TRPA (an...
Keywords: Absorption, Apoptosis, Atomic absorption spectroscopy, Cancer, Diabetes, Endocannabinoids, Gene expression, Growth factors, Neurotransmitters, Pulsed discharge ionization detector, Respiratory, Transduction, Vitamins
Delta 9-tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Chen JP, Paredes W, Li J, et al. Psychopharmacology 102(2), 156-62, (1990)
Interactions between μ-opioid receptor agonists and cannabinoid receptor agonists in rhesus monkeys: antinociception, drug discrimination, and drug self-administration. Maguire DR, Yang W, and France CP J. Pharmacol. Exp. Ther. 345(3), 354-62, (2013)
In vitro stability of free and glucuronidated cannabinoids in blood and plasma following controlled smoked cannabis. Scheidweiler KB, Schwope DM, Karschner EL, et al. Clin. Chem. 59(7), 1108-17, (2013)
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. Kinsey SG, Wise LE, Ramesh D, et al. J. Pharmacol. Exp. Ther. 345(3), 492-501, (2013)
Effects of a topically applied 2% delta-9-tetrahydrocannabinol ophthalmic solution on intraocular pressure and aqueous humor flow rate in clinically normal dogs. Fischer KM, Ward DA, and Hendrix DV Am. J. Vet. Res. 74(2), 275-80, (2013)
Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia. Geurts L, Muccioli GG, Delzenne NM, et al. PLoS ONE 8(2), e55963, (2013)
Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme. Hernán Pérez de la Ossa D, Lorente M, Gil-Alegre ME, et al. PLoS ONE 8(1), e54795, (2013)
In planta imaging of Δ⁹-tetrahydrocannabinolic acid in Cannabis sativa L. with hyperspectral coherent anti-Stokes Raman scattering microscopy. Garbacik ET, Korai RP, Frater EH, et al. J. Biomed. Opt. 18(4), 046009, (2013)
Has the intake of THC by cannabis users changed over the last decade? Evidence of increased exposure by analysis of blood THC concentrations in impaired drivers. Vindenes V, Strand DH, Kristoffersen L, et al. Forensic Sci. Int. 226(1-3), 197-201, (2013)
Effects of Δ9-THC on VIP-induced prolactin secretion in anterior pituitary cultures: evidence for the presence of functional cannabinoid CB1 receptors in pituitary cells. Rodriguez de Fonseca, F., et al. Brain Res. 841, 114-122, (1999)
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