|Related Categories||Antitumor Agents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cancer Research, Cell Biology,|
|color||white to off-white|
|solubility||DMSO: soluble20 mg/mL|
|Gene Information||human ... PPARA(5465), PPARG(5468)|
PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.
Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles1. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α2.
Certificate of Analysis
Certificate of Origin
Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism ...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 2011
Keywords: Apoptosis, Biological processes, Carboxylations, Diabetes, Gene expression, Gluconeogenesis, Glycolysis, Hormones, Metabolism, Metabolites, Transcription, Transduction
Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid...
Keywords: Anti-inflammatory agents, Atomic absorption spectroscopy, Cancer, Cell proliferation, Clinical, Diabetes, Diseases, Gene expression, Hormones, Inflammation, Ligands, Lipid Metabolism, Metabolic Pathways, Metabolism, Metabolites, Obesity, Oxidations, RNA immunoprecipitation, Transcription
Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing
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