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T2877 Sigma

3,3′,5-Triiodo-L-thyronine

≥95% (HPLC), powder

Synonym: O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Other Protein/Peptide Hormones,
InChI Key   AUYYCJSJGJYCDS-LBPRGKRZSA-N
assay   ≥95% (HPLC)
form   powder
optical activity   [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
mp   234-238 °C(lit.)
storage temp.   −20°C
Gene Information   human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)

Description

Packaging

1, 5 g in poly bottle

100, 250, 500 mg in poly bottle

Preparation Note

3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.

Application

3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay. The product can also be used for in vitro transfection of 293T cells.

Biochem/physiol Actions

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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Related Products

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Product #

Description

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709611 3,3′,5-Triiodothyronine-(tyrosine phenyl-13C6) hydrochloride, 99 atom % 13C, 95% (CP)
709719 3,3′,5′-Triiodothyronine-(diiodophenyl-13C6) hydrochloride, 99 atom % 13C, 95% (CP)
T5516 3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, BioXtra, suitable for cell culture
92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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