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T3258 Sigma

Tetracycline

≥88.0% (HPLC)

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,
assay   ≥88.0% (HPLC)
solubility   95% ethanol: soluble12.5 mg/mL
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   −20°C
Gene Information   human ... CYP1A2(1544), TERT(7015)

Description

Biochem/physiol Actions

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Price and Availability

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Tetracycline

≥98.0% (NT)

Tetracycline hydrochloride

≥95% (European Pharmacopoeia HPLC assay)

Tetracycline hydrochloride

meets USP testing specifications

Tetracycline hydrochloride

VETRANAL, analytical standard

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
22
Safety Statements (Europe) 
22-36
WGK Germany 
3
RTECS 
QI8750000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Minghua Wang et al Antimicrob. Agents Chemother. 53, 1892-7, (2009)

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Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. Vanessa G Allen et al Antimicrob. Agents Chemother. 55, 703-12, (2011)

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Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics. Anton Y Peleg et al Antimicrob. Agents Chemother. 53, 2605-9, (2009)

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Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. John D Szumowski et al Antimicrob. Agents Chemother. 51, 423-8, (2007)

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Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Andrew E Simor et al Antimicrob. Agents Chemother. 51, 3880-6, (2007)

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PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. Yongfang Li et al Antimicrob. Agents Chemother. 51, 2092-9, (2007)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action. Griffin MO, Ceballos G, and Villarreal FJ Pharmacol. Res. 63(2), 102-7, (2011)

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Rapid dissemination and diversity of CTX-M extended-spectrum beta-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America. Lucia Pallecchi et al Antimicrob. Agents Chemother. 51, 2720-5, (2007)

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Horizontal transfer of tetracycline resistance among Chlamydia spp. in vitro. R J Suchland et al Antimicrob. Agents Chemother. 53, 4604-11, (2009)

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Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania. Jennifer M Adams-Haduch et al Antimicrob. Agents Chemother. 52, 3837-43, (2008)

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Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer. Chatterjee A, Cook LC, Shu CC, et al. Proc. Natl. Acad. Sci. U. S. A. 110(17), 7086-90, (2013)

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Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. Mariana Castanheira et al Antimicrob. Agents Chemother. 52, 570-3, (2008)

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Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. Jürgen A Bohnert et al Antimicrob. Agents Chemother. 54, 3770-5, (2010)

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Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. Xiaoping Xu et al Antimicrob. Agents Chemother. 54, 1152-9, (2010)

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Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. Helio S Sader et al Antimicrob. Agents Chemother. 52, 1153-5, (2008)

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DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, et al. Nucleic Acids Res. 39, D1035-41., (2011)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores. Tighe A J. Cell Biol. 181(6), 893-901, (2008)

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Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori. Tan A, Fu G, Jin L, et al. Proc. Natl. Acad. Sci. U. S. A. 110(17), 6766-70, (2013)

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Mechanistic understanding of tetracycline sorption on waste tire powder and its chars as affected by Cu(2+) and pH. Lian F, Song Z, Liu Z, et al. Environ. Pollut. 178, 264-70, (2013)

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The tetracycline resistome. Thaker M, Spanogiannopoulos P, and Wright GD Cell. Mol. Life Sci. 67(3), 419-31, (2010)

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Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Vijaya Bharathi Srinivasan et al Antimicrob. Agents Chemother. 53, 5312-6, (2009)

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Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens. Nicholas Beckloff et al Antimicrob. Agents Chemother. 51, 4125-32, (2007)

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Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization. Muehlich S, Wang R, Lee SM, et al. Mol. Cell. Biol. 28(20), 6302-13, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. Michael Meehl et al Antimicrob. Agents Chemother. 51, 2679-89, (2007)

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Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. K G Byrne-Bailey et al Antimicrob. Agents Chemother. 53, 696-702, (2009)

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Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. M Indriati Hood et al Antimicrob. Agents Chemother. 54, 1029-41, (2010)

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Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system. L F Mandsberg et al Antimicrob. Agents Chemother. 53, 2483-91, (2009)

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Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). Mariana Castanheira et al Antimicrob. Agents Chemother. 53, 1225-7, (2009)

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Deglycosylation as a mechanism of inducible antibiotic resistance revealed using a global relational tree for one-component regulators. Cuthbertson L, Ahn SK, and Nodwell JR Chem. Biol. 20(2), 232-40, (2013)

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Decoding and engineering tetracycline biosynthesis. Pickens LB and Tang Y Metab. Eng. 11(2), 69-75, (2009)

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RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. Andrew M Bailey et al Antimicrob. Agents Chemother. 52, 3604-11, (2008)

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Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators. Edel O'Regan et al Antimicrob. Agents Chemother. 53, 1080-7, (2009)

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A novel autotransporter adhesin is required for efficient colonization during bubonic plague. Matthew B. Lawrenz et al Infect. Immun. 77, 317-26, (2009)

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Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia. Carlo McCalla et al Antimicrob. Agents Chemother. 52, 3441-3, (2008)

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Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Matthew G Blango et al Antimicrob. Agents Chemother. 54, 1855-63, (2010)

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Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac). Bo Zheng et al Antimicrob. Agents Chemother. 53, 735-47, (2009)

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Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Diego Pasini et al Genes Dev. 22, 1345-55, (2008)

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Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. Maria Pränting et al Antimicrob. Agents Chemother. 52, 2734-41, (2008)

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High diversity of extended-spectrum beta-lactamases in Escherichia coli isolates from Italian broiler flocks. Valeria Bortolaia et al Antimicrob. Agents Chemother. 54, 1623-6, (2010)

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Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. Sheng Chen et al Antimicrob. Agents Chemother. 51, 535-42, (2007)

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Tetracycline-related transcriptional regulation of the CTnDOT mobilization region. Waters JL, Wang GR, and Salyers AA J. Bacteriol. 195(24), 5431-8, (2013)

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Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. Tianyu Zhang et al Antimicrob. Agents Chemother. 54, 2806-13, (2010)

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Cicadapeptins I and II: new Aib-containing peptides from the entomopathogenic fungus Cordyceps heteropoda. Stuart B Krasnoff et al J. Nat. Prod. 68, 50-5, (2005)

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Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment. Barrowman J Mol. Biol. Cell 19(12), 5398-408, (2008)

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Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China. Yang Liu et al Antimicrob. Agents Chemother. 53, 2160-2, (2009)

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Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Feng Long et al Antimicrob. Agents Chemother. 52, 3052-60, (2008)

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High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. Nicole Wolter et al Antimicrob. Agents Chemother. 51, 1092-5, (2007)

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High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. Younis Baqi et al J. Med. Chem. 52, 3784-93, (2009)

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Serinocyclins A and B, cyclic heptapeptides from Metarhizium anisopliae. Stuart B Krasnoff et al J. Nat. Prod. 70, 1919-24, (2007)

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Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. Jingjing Zhao et al Antimicrob. Agents Chemother. 54, 4219-24, (2010)

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In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. Amar Bir Singh Sidhu et al J. Biol. Chem. 282, 2494-504, (2007)

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Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Sreedhar Subramanian et al Antimicrob. Agents Chemother. 52, 427-34, (2008)

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Update on acquired tetracycline resistance genes. Roberts, M.C. FEMS Microbiol. Lett. 245, 195-203, (2005)

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ampG gene of Pseudomonas aeruginosa and its role in ?-lactamase expression. Ying Zhang et al Antimicrob. Agents Chemother. 54, 4772-9, (2010)

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AI-2/LuxS is involved in increased biofilm formation by Streptococcus intermedius in the presence of antibiotics. Nibras A Ahmed et al Antimicrob. Agents Chemother. 53, 4258-63, (2009)

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Antimicrobial isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora. Maurice Ducret Awouafack et al J. Nat. Prod. 74, 272-8, (2011)

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Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. Amera Gibreel et al Antimicrob. Agents Chemother. 51, 3212-6, (2007)

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Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum ?-lactamase in serogroup O26. Glenn Buvens et al Antimicrob. Agents Chemother. 54, 4907-9, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. Helio S Sader et al Antimicrob. Agents Chemother. 53, 2171-5, (2009)

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Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes. Edel O'Regan et al Antimicrob. Agents Chemother. 54, 367-74, (2010)

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Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. Hervé Nicoloff et al Antimicrob. Agents Chemother. 51, 1293-303, (2007)

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CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. I Roca et al Antimicrob. Agents Chemother. 53, 4013-4, (2009)

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Two novel antibiotic resistance genes, tet(44) and ant(6)-Ib, are located within a transferable pathogenicity island in Campylobacter fetus subsp. fetus. Carlos Abril et al Antimicrob. Agents Chemother. 54, 3052-5, (2010)

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Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. Laura Calatayud et al Antimicrob. Agents Chemother. 51, 3240-6, (2007)

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Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Robert Bucki et al Antimicrob. Agents Chemother. 54, 2525-33, (2010)

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Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. Kenji Kurokawa et al Antimicrob. Agents Chemother. 53, 4025-7, (2009)

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Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. Nicole Wolter et al Antimicrob. Agents Chemother. 52, 435-40, (2008)

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Anti-oxidant and anti-bacterial activities of novel N'-arylmethylidene-2-(3, 4-dimethyl-5, 5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl) acetohydrazides. Matloob Ahmad et al Eur. J. Med. Chem. 45, 698-704, (2010)

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Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy. Carlo Melchiorre et al J. Med. Chem. 53, 5906-14, (2010)

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Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. Anna Fàbrega et al Antimicrob. Agents Chemother. 54, 1218-25, (2010)

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Oligochlorophens are potent inhibitors of Bacillus anthracis. Marie H Foss et al Antimicrob. Agents Chemother. 54, 3988-90, (2010)

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The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. Takehiko Mima et al Antimicrob. Agents Chemother. 54, 3113-20, (2010)

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Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. Michael L Beeton et al Antimicrob. Agents Chemother. 53, 2020-7, (2009)

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Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. Keith Miller et al Antimicrob. Agents Chemother. 52, 1940-4, (2008)

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Antibacterial diterpenes from Plectranthus ernstii. Michael Stavri et al J. Nat. Prod. 72, 1191-4, (2009)

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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Ashley A Reinke et al Bioorg. Med. Chem. Lett. 19, 4952-7, (2009)

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Antimicrobial susceptibility and mechanisms of resistance in Shigella and Salmonella isolates from children under five years of age with diarrhea in rural Mozambique. Inácio Mandomando et al Antimicrob. Agents Chemother. 53, 2450-4, (2009)

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Role of Cj1211 in natural transformation and transfer of antibiotic resistance determinants in Campylobacter jejuni. Byeonghwa Jeon et al Antimicrob. Agents Chemother. 52, 2699-708, (2008)

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Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis. Olga Danilchanka et al Antimicrob. Agents Chemother. 52, 2503-11, (2008)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Visible-light-mediated Sr-Bi2O3 photocatalysis of tetracycline: kinetics, mechanisms and toxicity assessment. Niu J, Ding S, Zhang L, et al. Chemosphere 93(1), 1-8, (2013)

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In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection. Kukavica-Ibrulj I J. Bacteriol. 190(8), 2804-13, (2008)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Increased risk of acute pancreatitis among tetracycline users in a Swedish population-based case-control study Rickard Ljung, Jesper Lagergren, et al. Gut 10.1136, 300949, (2011)

The effects of tetracycline-loaded silk fibroin membrane on proliferation and osteogenic potential of mesenchymal stem cells. Jin SH, Kweon H, Park JB, et al. J. Surg. Res. 192(2), e1-9, (2014)

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Helicobacter pylori first-line and rescue treatments in the presence of penicillin allergy. Gisbert JP, Barrio J, Modolell I, et al. Dig. Dis. Sci. 60(2), 458-64, (2015)

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Persistence of livestock-associated antibiotic-resistant Staphylococcus aureus among industrial hog operation workers in North Carolina over 14 days. Nadimpalli M, Rinsky JL, Wing S, et al. Occup. Environ. Med. 72(2), 90-9, (2015)

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Early detection of heterotopic ossification using near-infrared optical imaging reveals dynamic turnover and progression of mineralization following Achilles tenotomy and burn injury. Perosky JE, Peterson JR, Eboda ON, et al. J. Orthop. Res. 32(11), 1416-23, (2014)

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Macrolide- and tetracycline-resistance determinants of colonizing group B streptococcus in women in Egypt. Shabayek S and Abdalla S J. Med. Microbiol. 63(Pt 10), 1324-7, (2014)

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[Alterations of prooxidant-antioxidant system of rat liver at ethanol and tetracycline action]. Nedoshytko KhIu Ukr. Biokhim. Zh. 85(5), 154-62, (2013)

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Time to deal with antibiotics. Kennedy D Science 342(6160), 777, (2013)

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Patterns of ambulatory care usage and leading treatments for rosacea. Davis SA and Feldman SR J. Dermatolog. Treat. 25(4), 275-7, (2014)

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Extensive esophageal damage resembling carcinoma due to tetracycline intake. Karaahmet F, Coşkun Y, Erarslan E, et al. Endoscopy 45 Suppl 2 UCTN, E258, (2013)

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Escherichia coli tetracycline efflux determinants in relation to tetracycline residues in chicken. S N AB, B M AM, A S AA, et al. Asian Pac. J. Trop. Med. 6(9), 718-22, (2013)

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Human T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression reflect ERα/ERβ ratios in rat and human breast tissue. Evers NM, van de Klundert TM, van Aesch YM, et al. Toxicol. In Vitro 27(6), 1753-61, (2013)

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Bismuth + metronidazole + tetracycline. Why risk adding bismuth? Prescrire Int. 22(137), 89-92, (2013)

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Skin conditions: new drugs for managing skin disorders. Nguyen T and Zuniga R FP Essent. 407, 11-6, (2013)

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Adsorption removal of tetracycline from aqueous solution by anaerobic granular sludge: equilibrium and kinetic studies. Li K, Ji F, Liu Y, et al. Water Sci. Technol. 67(7), 1490-6, (2013)

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Altering the selection capabilities of common cloning vectors via restriction enzyme mediated gene disruption. Manna S, Harman A, Accari J, et al. BMC Res. Notes 6, 85, (2013)

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Generation of stable human cell lines with Tetracycline-inducible (Tet-on) shRNA or cDNA expression. Gomez-Martinez M, Schmitz D, and Hergovich A J. Vis. Exp. (73), e50171, (2013)

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Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. Bapurao B Shingate et al Eur. J. Med. Chem. 46, 3681-9, (2011)

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Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. María Margarita Rodríguez et al Antimicrob. Agents Chemother. 54, 3070-1, (2010)

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Part X. Tetracycline and glycylcycline antimicrobials. Vincent S, Bronze MS, Cooper TW, et al. J. Okla. State Med. Assoc. 100(6), 241-7, (2007)

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[Tetracycline]. Totsuka K Nihon Rinsho. 65 Suppl 3, 675-80, (2007)

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Clinical inquiries. Does treatment of acne with Retin A and tetracycline cause adverse effects? Kelly BF, Burroughs M, and Mertens M J. Fam. Pract. 53(4), 316-8, (2004)

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[Effect of tetracycline on metabolic processes in bones]. Folwarczna J Postepy. Hig. Med. Dosw. 57(2), 185-98, (2003)

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Characterization of tetracycline resistant bacterial community in saline activated sludge using batch stress incubation with high-throughput sequencing analysis. Li B, Zhang X, Guo F, et al. Water Res. 47(13), 4207-16, (2013)

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Antibacterial properties and mode of action of a short acyl-lysyl oligomer. Fadia Zaknoon et al Antimicrob. Agents Chemother. 53, 3422-9, (2009)

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Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives. Afsheen Arshad et al Eur. J. Med. Chem. 46, 3788-94, (2011)

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Combined inactivation of lon and ycgE decreases multidrug susceptibility by reducing the amount of OmpF porin in Escherichia coli. Valérie Duval et al Antimicrob. Agents Chemother. 53, 4944-8, (2009)

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Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. Ying-Tsong Chen et al Antimicrob. Agents Chemother. 51, 3004-7, (2007)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum. T N C Ramya et al Antimicrob. Agents Chemother. 51, 307-16, (2007)

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Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. J A Severin et al Antimicrob. Agents Chemother. 54, 5413-7, (2010)

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Transferable quinolone resistance in Vibrio cholerae. Hong Bin Kim et al Antimicrob. Agents Chemother. 54, 799-803, (2010)

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Simple piggyBac transposon-based mammalian cell expression system for inducible protein production. Li Z, Michael IP, Zhou D, et al. Proc. Natl. Acad. Sci. U. S. A. 110(13), 5004-9, (2013)

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Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent. Xiao-Yi Xiao et al J. Med. Chem. 55, 597-605, (2012)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion. Sin-Sien Jiang et al Antimicrob. Agents Chemother. 54, 1564-71, (2010)

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In vivo gene regulation using tetracycline-regulatable systems. Stieger K, Belbellaa B, Le Guiner C, et al. Adv. Drug Deliv. Rev. 61(7-8), 527-41, (2009)

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First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 52, 2244-6, (2008)

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Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Neil Woodford et al Antimicrob. Agents Chemother. 53, 4472-82, (2009)

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Emergence of resistance among USA300 methicillin-resistant Staphylococcus aureus isolates causing invasive disease in the United States. Linda K McDougal et al Antimicrob. Agents Chemother. 54, 3804-11, (2010)

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Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. Corinna Kehrenberg et al Antimicrob. Agents Chemother. 53, 779-81, (2009)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Amélie Carrër et al Antimicrob. Agents Chemother. 52, 2950-4, (2008)

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AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Laurence Damier-Piolle et al Antimicrob. Agents Chemother. 52, 557-62, (2008)

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Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. Margot E Grinwis et al Antimicrob. Agents Chemother. 54, 2823-9, (2010)

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Airway-specific inducible transgene expression using aerosolized doxycycline. Tata PR, Pardo-Saganta A, Prabhu M, et al. Am. J. Respir. Cell. Mol. Biol. 49(6), 1048-56, (2013)

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Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. Bernard J Wolff et al Antimicrob. Agents Chemother. 52, 3542-9, (2008)

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Complexities in tetracycline analysis-chemistry, matrix extraction, cleanup, and liquid chromatography. Anderson CR, Rupp HS, and Wu WH J. Chromatogr. A 1075(1-2), 23-32, (2005)

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LH receptor gene expression is essentially absent in breast tumor tissue: implications for treatment. Kuijper TM Mol. Cell. Endocrinol. 302(1), 58-64, (2009)

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Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Yudong Liu et al Antimicrob. Agents Chemother. 53, 512-8, (2009)

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Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. Pattarachai Kiratisin et al Antimicrob. Agents Chemother. 52, 2818-24, (2008)

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Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. Longzhu Cui et al Antimicrob. Agents Chemother. 53, 1231-4, (2009)

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New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Kunikazu Yamane et al Antimicrob. Agents Chemother. 51, 3354-60, (2007)

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In vitro activity of telavancin against resistant gram-positive bacteria. Kevin M Krause et al Antimicrob. Agents Chemother. 52, 2647-52, (2008)

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Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Bruno Périchon et al Antimicrob. Agents Chemother. 51, 2464-9, (2007)

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First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. Lei Dai et al Antimicrob. Agents Chemother. 54, 3953-5, (2010)

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Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France. A Morvan et al Antimicrob. Agents Chemother. 54, 2728-31, (2010)

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In vitro activities of panduratin A against clinical Staphylococcus strains. Yaya Rukayadi et al Antimicrob. Agents Chemother. 53, 4529-32, (2009)

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A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin. Aygün O, Svejstrup J, and Liu Y Proc. Natl. Acad. Sci. U. S. A. 105(25), 8580-4, (2008)

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ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Yousef M Abouzeed et al Antimicrob. Agents Chemother. 52, 2428-34, (2008)

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Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bryan Knuckley et al Bioorg. Med. Chem. 16, 739-45, (2008)

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High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. Linda M Weigel et al Antimicrob. Agents Chemother. 51, 231-8, (2007)

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Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. Kristina Kadlec et al Antimicrob. Agents Chemother. 53, 3589-91, (2009)

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Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. Andrea T Fessler et al Antimicrob. Agents Chemother. 55, 373-5, (2011)

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Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain. Kristina Kadlec et al Antimicrob. Agents Chemother. 54, 915-8, (2010)

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Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. Emma Padilla et al Antimicrob. Agents Chemother. 54, 177-83, (2010)

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8-Azatetracyclines: synthesis and evaluation of a novel class of tetracycline antibacterial agents. Roger B Clark et al J. Med. Chem. 54, 1511-28, (2011)

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In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. Jong Hwa Yum et al Antimicrob. Agents Chemother. 51, 2591-3, (2007)

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Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. Annette Leon et al J. Med. Chem. 49, 7331-41, (2006)

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Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. Zuzana Svetlíková et al Antimicrob. Agents Chemother. 53, 4015-8, (2009)

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Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L). Kristina Kadlec et al Antimicrob. Agents Chemother. 53, 776-8, (2009)

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Chicken faecal microbiota and disturbances induced by single or repeated therapy with tetracycline and streptomycin. Videnska P, Faldynova M, Juricova H, et al. BMC Vet. Res. 9, 30, (2013)

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Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. Sébastien Coyne et al Antimicrob. Agents Chemother. 54, 333-40, (2010)

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Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 3801-4, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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In vitro activities of tigecycline against clinical isolates of Aeromonas, Vibrio, and Salmonella species in Taiwan. Chia-Ying Liu et al Antimicrob. Agents Chemother. 52, 2677-9, (2008)

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Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus. Mary Jo Cenizal et al Antimicrob. Agents Chemother. 51, 2628-30, (2007)

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Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. Anna Baraniak et al Antimicrob. Agents Chemother. 53, 4565-7, (2009)

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In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. Kristi L Frank et al Antimicrob. Agents Chemother. 51, 888-95, (2007)

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Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs. Cuixiang Sun et al J. Med. Chem. 54, 3704-31, (2011)

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An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds. Bunikis I PLoS Pathog. 4(2), e1000009, (2008)

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Poly(ethylene glycol) (PEG-400) as an alternative reaction solvent for the synthesis of some new 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazolines and their in vitro antimicrobial evaluation. Bhaskar S Dawane et al Eur. J. Med. Chem. 45, 387-92, (2010)

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Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene. Andrea Brenciani et al Antimicrob. Agents Chemother. 51, 1209-16, (2007)

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Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. Lotta Siira et al Antimicrob. Agents Chemother. 53, 2066-73, (2009)

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Urea/thiourea derivatives of quinazolinone-lysine conjugates: synthesis and structure-activity relationships of a new series of antimicrobials. G P Suresha et al Eur. J. Med. Chem. 46, 2530-40, (2011)

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erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003. Ileana Cochetti et al Antimicrob. Agents Chemother. 52, 1285-90, (2008)

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Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin. Daniel R Gentry et al Antimicrob. Agents Chemother. 51, 2048-52, (2007)

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Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. Daniel R Gentry et al Antimicrob. Agents Chemother. 52, 4507-9, (2008)

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Synthesis and antimicrobial activity of highly functionalised novel ?-lactam grafted spiropyrrolidines and pyrrolizidines. Natarajan Arumugam et al Eur. J. Med. Chem. 46, 600-7, (2011)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday. Yang L J. Orthop. Res. 27(2), 169-75, (2009)

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Structure-activity relationship of antibacterial chalcones. Hugo Pereira Avila et al Bioorg. Med. Chem. 16, 9790-4, (2008)

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Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. Mirva Lehtopolku et al Antimicrob. Agents Chemother. 54, 1232-6, (2010)

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Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. Thithiwat May et al Antimicrob. Agents Chemother. 53, 4628-39, (2009)

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Review on immunoanalytical determination of tetracycline and sulfonamide residues in edible products. Pastor-Navarro N, Maquieira A, and Puchades R Anal. Bioanal. Chem 395(4), 907-20, (2009)

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Polyamine effects on antibiotic susceptibility in bacteria. Dong-Hyeon Kwon et al Antimicrob. Agents Chemother. 51, 2070-7, (2007)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain. Kristina Kadlec et al Antimicrob. Agents Chemother. 54, 3475-7, (2010)

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Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms. F Buchholz et al Antimicrob. Agents Chemother. 54, 312-9, (2010)

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Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines. N. Duewelhenke, O. Krut, et al. Antimicrob. Agents Chemother. 51, 54-63, (2007)

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Controlled release and antibacterial activity of antibiotic-loaded electrospun halloysite/poly(lactic-co-glycolic acid) composite nanofibers. Qi R, Guo R, Zheng F, et al. Colloids Surf. B Biointerfaces 110, 148-55, (2013)

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Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis. Claudio Palmieri et al Antimicrob. Agents Chemother. 55, 631-6, (2011)

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In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. W T M Jansen et al Antimicrob. Agents Chemother. 51, 3420-4, (2007)

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Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. C R Bourne et al Antimicrob. Agents Chemother. 54, 3825-33, (2010)

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Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines. K Karthikeyan et al Eur. J. Med. Chem. 45, 3446-52, (2010)

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Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol. Imran Nafees Siddiqui et al J. Nat. Prod. 74, 365-73, (2011)

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Interdomain loop mutation Asp190Cys of the tetracycline efflux transporter TetA(B) decreases affinity for substrate. Frédéric M Sapunaric et al Antimicrob. Agents Chemother. 51, 3036-7, (2007)

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Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents. Tarik El-Sayed Ali et al Eur. J. Med. Chem. 44, 4385-92, (2009)

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Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 53, 1260-3, (2009)

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Substrate-induced protein stabilization reveals a predominant contribution from mature proteins to peptides presented on MHC class I. Colbert JD, Farfán-Arribas DJ, and Rock KL J. Immunol. 191(11), 5410-9, (2013)

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High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. Viola C Y Chow et al Antimicrob. Agents Chemother. 51, 2508-13, (2007)

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Synthesis, antibacterial and antimycobacterial activities of some new 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines. Kalam Sirisha et al Eur. J. Med. Chem. 46, 1564-71, (2011)

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In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 54, 2704-6, (2010)

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Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. Hideaki Maseda et al Antimicrob. Agents Chemother. 53, 5230-5, (2009)

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Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. Ryoichi Hamasuna et al Antimicrob. Agents Chemother. 53, 4938-9, (2009)

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Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes. Chika Ishikawa et al Antimicrob. Agents Chemother. 53, 1760-5, (2009)

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Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility. Noriyuki Nagano et al Antimicrob. Agents Chemother. 52, 4258-67, (2008)

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Influence of high mutation rates on the mechanisms and dynamics of in vitro and in vivo resistance development to single or combined antipseudomonal agents. V Plasencia et al Antimicrob. Agents Chemother. 51, 2574-81, (2007)

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Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives. Govindasami Periyasami et al Eur. J. Med. Chem. 44, 959-66, (2009)

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Synthesis, antimicrobial activity and structure-activity relationship study of N,N-dibenzyl-cyclohexane-1,2-diamine derivatives. Mukul Sharma et al Eur. J. Med. Chem. 46, 480-7, (2011)

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Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose. Sirangelo I and Irace G Expert Opin. Ther. Targets 14(12), 1311-21, (2010)

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The macrolide resistance genes erm(B) and mef(E) are carried by Tn2010 in dual-gene Streptococcus pneumoniae isolates belonging to clonal complex CC271. Maria Del Grosso et al Antimicrob. Agents Chemother. 51, 4184-6, (2007)

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Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. Astrid Pérez et al Antimicrob. Agents Chemother. 51, 3247-53, (2007)

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IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. Timothy J Welch et al Antimicrob. Agents Chemother. 53, 845-6, (2009)

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Synthesis and biological evaluation of a novel series of pyrazole chalcones as anti-inflammatory, antioxidant and antimicrobial agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 17, 8168-73, (2009)

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Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Hwang-Soo Joo et al Antimicrob. Agents Chemother. 54, 4942-4, (2010)

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Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. Milagrosa Montes et al Antimicrob. Agents Chemother. 54, 93-7, (2010)

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Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. Alvaro San Millan et al Antimicrob. Agents Chemother. 53, 3399-404, (2009)

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In vitro susceptibility of isolates of Francisella tularensis types A and B from North America. Sandra K Urich et al Antimicrob. Agents Chemother. 52, 2276-8, (2008)

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Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. Hayssam Khalil et al Antimicrob. Agents Chemother. 52, 1635-41, (2008)

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Mayamycin, a cytotoxic polyketide from a Streptomyces strain isolated from the marine sponge Halichondria panicea. Imke Schneemann et al J. Nat. Prod. 73, 1309-12, (2010)

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Antimicrobial susceptibility and mutations involved in clarithromycin resistance in Helicobacter pylori isolates from patients in the western central region of Colombia. Adalucy Alvarez et al Antimicrob. Agents Chemother. 53, 4022-4, (2009)

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Novel pyridazine derivatives: Synthesis and antimicrobial activity evaluation. N G Kandile et al Eur. J. Med. Chem. 44, 1989-96, (2009)

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The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. Kin Y Tam et al J. Med. Chem. 53, 392-401, (2010)

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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Christopher A Elkins et al Antimicrob. Agents Chemother. 51, 923-9, (2007)

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Synthesis and antimicrobial activity of (E) stilbene derivatives. Sabrina Albert et al Bioorg. Med. Chem. 19, 5155-66, (2011)

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Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. Sara Thulin Hedberg et al Antimicrob. Agents Chemother. 53, 1561-6, (2009)

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Bioactive isocoumarins isolated from the endophytic fungus Microdochium bolleyi. Wen Zhang et al J. Nat. Prod. 71, 1078-81, (2008)

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Modifying Culture Conditions In Chemical Library Screening Identifies Alternative Inhibitors Of Mycobacteria. Miller, C.H., et al. Antimicrob. Agents Chemother. 53, 5279-83, (2009)

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Mosaic tetracycline resistance genes and their flanking regions in Bifidobacterium thermophilum and Lactobacillus johnsonii. Angela H A M van Hoek et al Antimicrob. Agents Chemother. 52, 248-52, (2008)

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Occurrence of tetracycline resistance genes among Escherichia coli isolates from the phase 3 clinical trials for tigecycline. Margareta Tuckman et al Antimicrob. Agents Chemother. 51, 3205-11, (2007)

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A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction. Guojun Wang et al Antimicrob. Agents Chemother. 53, 1019-26, (2009)

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Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. Renato Pires et al Antimicrob. Agents Chemother. 54, 2677-80, (2010)

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Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Giovanni Appendino et al J. Nat. Prod. 71, 1427-30, (2008)

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Antibacterial polyketides from the jellyfish-derived fungus Paecilomyces variotii. Juan Liu et al J. Nat. Prod. 74, 1826-9, (2011)

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The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii. Robert W Huigens et al Bioorg. Med. Chem. 18, 663-74, (2010)

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Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California. Valentine SC, Contreras D, Tan S, et al. J. Clin. Microbiol. 46(8), 2499-507, (2008)

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Comparison of disk diffusion and agar dilution methods for erythromycin, ciprofloxacin, and tetracycline susceptibility testing of Campylobacter coli and for tetracycline susceptibility testing of Campylobacter jejuni subsp. jejuni. Christiane Gaudreau et al Antimicrob. Agents Chemother. 52, 4475-7, (2008)

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A new tetracycline efflux gene, tet(40), is located in tandem with tet(O/32/O) in a human gut firmicute bacterium and in metagenomic library clones. Katarzyna A Kazimierczak et al Antimicrob. Agents Chemother. 52, 4001-9, (2008)

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Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. Roseanne A Ressner et al Antimicrob. Agents Chemother. 52, 2750-4, (2008)

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Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. Lilia Chérigo et al J. Nat. Prod. 71, 1037-45, (2008)

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Synthesis, characterization and evaluation of antibacterial activity of some thiazolo[3,2-b][1,2,4]triazole incorporating diphenylsulfone moieties. Stefania-Felicia Barbuceanu et al Eur. J. Med. Chem. 44, 4752-7, (2009)

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An efficient synthesis of highly functionalized novel chromeno[4,3-b]pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents. Natarajan Arumugam et al Bioorg. Med. Chem. Lett. 22, 1375-9, (2012)

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Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. Stefanie Heller et al Antimicrob. Agents Chemother. 51, 1956-61, (2007)

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Antibiotic bisanthraquinones produced by a streptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinata. Aaron M Socha et al J. Nat. Prod. 69, 1070-3, (2006)

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Pyrazolopyrimidinediones are selective agents for Helicobacter pylori that suppress growth through inhibition of glutamate racemase (MurI). B L M de Jonge et al Antimicrob. Agents Chemother. 53, 3331-6, (2009)

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Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole. Namdev S Vatmurge et al Bioorg. Med. Chem. Lett. 18, 2043-7, (2008)

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Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Alita A Miller et al Antimicrob. Agents Chemother. 52, 2806-12, (2008)

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Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. Elena N Ilina et al Antimicrob. Agents Chemother. 52, 2175-82, (2008)

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Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. Philippe Villain-Guillot et al J. Med. Chem. 50, 4195-204, (2007)

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Synthesis and antimicrobial activity of 3-arylamino-1-chloropropan-2-ols. Ashok K Prasad et al Bioorg. Med. Chem. Lett. 18, 2156-61, (2008)

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Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. S Faure et al Antimicrob. Agents Chemother. 54, 164-9, (2010)

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In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci. Daniel Llull et al Antimicrob. Agents Chemother. 51, 1844-8, (2007)

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Tetracycline resistance in group a streptococci: emergence on a global scale and influence on multiple-drug resistance. Vanessa Ayer et al Antimicrob. Agents Chemother. 51, 1865-8, (2007)

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Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics. Yuefen Zhou et al Bioorg. Med. Chem. Lett. 17, 1206-10, (2007)

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Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. Rebecca Steidl et al Antimicrob. Agents Chemother. 52, 2923-5, (2008)

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Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). Elia Gómez G de la Pedrosa et al Antimicrob. Agents Chemother. 52, 1964-9, (2008)

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Tetracycline resistance gene tet(W) in the pathogenic bacterium Clostridium difficile. Patrizia Spigaglia et al Antimicrob. Agents Chemother. 52, 770-3, (2008)

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Polyacylated oligosaccharides from medicinal Mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus. Rogelio Pereda-Miranda et al J. Nat. Prod. 69, 406-9, (2006)

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Synthesis and biological screening of a combinatorial library of beta-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 18, 2060-5, (2010)

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Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. Jin-Feng Hu et al J. Nat. Prod. 69, 585-90, (2006)

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Multidrug resistance pump AcrAB-TolC is required for high-level, Tet(A)-mediated tetracycline resistance in Escherichia coli Ricardo E. de Cristóbal, et al. J. Antimicrob. Chemother. 58, 31-36, (2006)

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Guiding differentiation of stem cells in vivo by tetracycline-controlled expression of key transcription factors. Kozlova EN and Berens C Cell. Transplant. 21(12), 2537-54, (2012)

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Synthesis and antimicrobial activity of novel pyrazolo[3,4-d]pyrimidin derivatives. Chandrahas N Khobragade et al Eur. J. Med. Chem. 45, 1635-8, (2010)

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Lipophosphonoxins: new modular molecular structures with significant antibacterial properties. Dominik Rejman et al J. Med. Chem. 54, 7884-98, (2011)

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One-pot synthesis and antibacterial activities of pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine-dione derivatives. Ayoob Bazgir et al Bioorg. Med. Chem. Lett. 18, 5800-3, (2008)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Microwave-assisted synthesis of N-alkylated benzotriazole derivatives: antimicrobial studies. S Nanjunda Swamy et al Bioorg. Med. Chem. Lett. 16, 999-1004, (2006)

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Tetracycline resistance in Ureaplasma spp. and Mycoplasma hominis: prevalence in Bordeaux, France, from 1999 to 2002 and description of two tet(M)-positive isolates of M. hominis susceptible to tetracyclines. S Dégrange et al Antimicrob. Agents Chemother. 52, 742-4, (2008)

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Phytoremediation potential of vetiver grass [Chrysopogon zizanioides (L.)] for tetracycline. Datta R, Das P, Smith S, et al. Int. J. Phytoremediation 15(4), 343-51, (2013)

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Design and synthesis of potent Gram-negative specific LpxC inhibitors. U Faruk Mansoor et al Bioorg. Med. Chem. Lett. 21, 1155-61, (2011)

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Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens. Govindasami Periyasami et al Bioorg. Med. Chem. Lett. 18, 2342-5, (2008)

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In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. Michael J Pucci et al Antimicrob. Agents Chemother. 51, 1259-67, (2007)

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Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. Radosław Izdebski et al Antimicrob. Agents Chemother. 51, 1155-63, (2007)

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Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. Naz M Aghatabay et al Eur. J. Med. Chem. 42, 205-13, (2007)

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New 6-amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazin-6-ones: synthesis, characterization and antibacterial activity evaluation. Gabriela Laura Almajan et al Eur. J. Med. Chem. 45, 3191-5, (2010)

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Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis. G C Kedar et al Antimicrob. Agents Chemother. 52, 2009-13, (2008)

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Synthesis of novel carbazole based macrocyclic amides as potential antimicrobial agents. Perumal Rajakumar et al Eur. J. Med. Chem. 44, 3040-5, (2009)

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Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study. Navarro-Rodriguez T, Silva FM, Barbuti RC, et al. BMC Gastroenterol. 13, 56, (2013)

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Cytotoxic ring A-modified steroid analogues derived from Grundmann's ketone. Christoph D Mayer et al Eur. J. Med. Chem. 46, 3227-36, (2011)

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Syntheses and antibacterial activity of phendioxy substituted cyclic enediynes. Mukesh Chandra Joshi et al Bioorg. Med. Chem. Lett. 17, 3226-30, (2007)

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Insights into the evolution of gene organization and multidrug resistance from Klebsiella pneumoniae plasmid pKF3-140. Bai J, Liu Q, Yang Y, et al. Gene 519(1), 60-6, (2013)

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Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents. Khalid Mohammed Hassan Hilmy et al Eur. J. Med. Chem. 45, 5243-50, (2010)

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Antimicrobial activity of rationally designed amino terminal modified peptides. Gopal Singh Bisht et al Bioorg. Med. Chem. Lett. 17, 4343-6, (2007)

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Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. Jeong Hwan Shin et al Antimicrob. Agents Chemother. 51, 2625-7, (2007)

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Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-diamino-piperidinyl triazines. Yuefen Zhou et al Bioorg. Med. Chem. Lett. 16, 5451-6, (2006)

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Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials. Peng-Cheng Lv et al Eur. J. Med. Chem. 44, 1779-87, (2009)

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Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity. Sánchez AR, Rogers RS, and Sheridan PJ Int. J. Dermatol. 43(10), 709-15, (2004)

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Selective bone targeting 5-fluorouracil prodrugs: synthesis and preliminary biological evaluation. Liang Ouyang et al Bioorg. Med. Chem. 19, 3750-6, (2011)

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Interactions of tetracycline with Cd (II), Cu (II) and Pb (II) and their cosorption behavior in soils. Zhao Y, Tan Y, Guo Y, et al. Environ. Pollut. 180, 206-13, (2013)

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Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number. Charles R Dean et al Antimicrob. Agents Chemother. 51, 1004-10, (2007)

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New composite genetic element of the Tn916 family with dual macrolide resistance genes in a Streptococcus pneumoniae isolate belonging to clonal complex 271. Maria Del Grosso et al Antimicrob. Agents Chemother. 53, 1293-4, (2009)

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Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. González-Pleiter M, Gonzalo S, Rodea-Palomares I, et al. Water Res. 47(6), 2050-64, (2013)

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Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens. Natarajan Arumugam et al Bioorg. Med. Chem. Lett. 20, 3698-702, (2010)

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Macrolide antibiotic-mediated downregulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa. Makoto Sugimura et al Antimicrob. Agents Chemother. 52, 4141-4, (2008)

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Synthesis and antibacterial activity of some new thiadiaza/triazaphospholes, thiadiaza/triaza/tetrazaphosphinines and thiadiaza/tetrazaphosphepines containing 1,2,4-triazinone moiety. Tarik El-Sayed Ali et al Eur. J. Med. Chem. 44, 4539-46, (2009)

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Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. Wensi S Hu et al Antimicrob. Agents Chemother. 53, 3248-55, (2009)

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The PhoQ-activating potential of antimicrobial peptides contributes to antimicrobial efficacy and is predictive of the induction of bacterial resistance. Jason Kindrachuk et al Antimicrob. Agents Chemother. 51, 4374-81, (2007)

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Biochemical characterization of PER-2 and genetic environment of blaPER-2. Pablo Power et al Antimicrob. Agents Chemother. 51, 2359-65, (2007)

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Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli. Manish Goswami et al Antimicrob. Agents Chemother. 51, 1119-22, (2007)

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Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents. Sudhir N Bavikar et al Bioorg. Med. Chem. Lett. 18, 5512-7, (2008)

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Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 53, 843-4, (2009)

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Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis. Kang YK Cancer Res. 68(19), 7887-96, (2008)

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Stereoselective synthesis of hexahydro-3-methyl-1-arylchromeno[3,4-b]pyrrole and its annulated heterocycles as potent antimicrobial agents for human pathogens. S Purushothaman et al Bioorg. Med. Chem. Lett. 20, 7288-91, (2010)

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Red scalp disease--a rosacea-like dermatosis of the scalp? Successful therapy with oral tetracycline. Oberholzer PA, Nobbe S, Kolm I, et al. Dermatology 219(2), 179-81, (2009)

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Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes. Carlos Salas et al Antimicrob. Agents Chemother. 52, 1503-5, (2008)

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Efficient synthesis and biological evaluation of proximicins A, B and C. Federico Brucoli et al Bioorg. Med. Chem. 20, 2019-24, (2012)

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Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. Ronald N Jones et al Antimicrob. Agents Chemother. 54, 4518-9, (2010)

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Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides. Galyna G Berest et al Eur. J. Med. Chem. 46, 6066-74, (2011)

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Design, synthesis and docking studies of new furobenzopyranones and pyranobenzopyranones as photoreagent towards DNA and as antimicrobial agents. Nahla A H Farag et al Eur. J. Med. Chem. 45, 317-25, (2010)

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Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. Naz M Aghatabay et al Eur. J. Med. Chem. 44, 4681-9, (2009)

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Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. Que-Tien Tran et al Antimicrob. Agents Chemother. 53, 1652-6, (2009)

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Detection of the erythromycin rRNA methylase gene erm(A) in Enterococcus faecalis. Karin Schwaiger et al Antimicrob. Agents Chemother. 52, 2994-5, (2008)

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Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. Ken B Waites et al Antimicrob. Agents Chemother. 52, 3776-8, (2008)

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In vitro inhibitory activity of boropinic acid against Helicobacter pylori. Francesco Epifano et al Bioorg. Med. Chem. Lett. 16, 5523-5, (2006)

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Synthesis and antibacterial activity evaluation of metronidazole-triazole conjugates. Beena et al Bioorg. Med. Chem. Lett. 19, 1396-8, (2009)

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First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. Alexandros Ikonomidis et al Antimicrob. Agents Chemother. 51, 3038-9, (2007)

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Characterization of macrolide efflux pump mef subclasses detected in clinical isolates of Streptococcus pyogenes isolated between 1999 and 2005. J Blackman Northwood et al Antimicrob. Agents Chemother. 53, 1921-5, (2009)

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Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus. Krzysztof Sieradzki et al Antimicrob. Agents Chemother. 52, 505-12, (2008)

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Antimicrobial phenolic abietane diterpene from Lycopus europaeus L. (Lamiaceae). Niko Radulovi? et al Bioorg. Med. Chem. Lett. 20, 4988-91, (2010)

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High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. Véronique Duval et al Antimicrob. Agents Chemother. 53, 4957-8, (2009)

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Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. Jun Okuda et al Antimicrob. Agents Chemother. 54, 4917-9, (2010)

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Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. Gill SC, et al. Antimicrob. Agents Chemother. 5th ed., 54, 1678-1683, (2010)

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Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. Christopher A Elkins et al Antimicrob. Agents Chemother. 54, 1007-15, (2010)

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Dose response and clonal variability of lentiviral tetracycline-regulated vectors in murine hematopoietic cells. Kustikova OS, Stahlhut M, Ha TC, et al. Exp. Hematol. 42(7), 505-515.e7, (2014)

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Native efflux pumps contribute resistance to antimicrobials of skin and the ability of Staphylococcus aureus to colonize skin. Truong-Bolduc QC, Villet RA, Estabrooks ZA, et al. J. Infect. Dis. 209(9), 1485-93, (2014)

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Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. Naz M Aghatabay et al Eur. J. Med. Chem. 42, 1069-75, (2007)

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Synthesis of some novel imidazole-based dicationic carbazolophanes as potential antibacterials. Perumal Rajakumar et al Bioorg. Med. Chem. Lett. 18, 4416-9, (2008)

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N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. Manish Goswami et al Antimicrob. Agents Chemother. 54, 3529-30, (2010)

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Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. Naz Mohammed Aghatabay et al Eur. J. Med. Chem. 44, 365-72, (2009)

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Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. Timothy J Opperman et al Bioorg. Med. Chem. 18, 2123-30, (2010)

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Neisseria gonorrhoeae antimicrobial resistance among men who have sex with men and men who have sex exclusively with women: the Gonococcal Isolate Surveillance Project, 2005-2010. Kirkcaldy RD, Zaidi A, Hook EW, et al. Ann. Intern. Med. 158(5 Pt 1), 321-8, (2013)

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Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. Chang-Hsing Liang et al Bioorg. Med. Chem. Lett. 15, 2123-8, (2005)

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Pharmacokinetics and residues of tetracycline in crucian carp muscle using capillary electrophoresis on-line coupled with electrochemiluminescence detection. Deng B, Xu Q, Lu H, et al. Food Chem. 134(4), 2350-4, (2012)

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Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases. Aurélien Vidal et al Bioorg. Med. Chem. 15, 2368-74, (2007)

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Synthesis and antibacterial activity of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives. Deepak Kumar et al Bioorg. Med. Chem. Lett. 20, 893-5, (2010)

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Antibiotic resistance of Helicobacter pylori in Mashhad, Iran. Zendedel A, Moradimoghadam F, Almasi V, et al. J. Pak. Med. Assoc. 63(3), 336-9, (2013)

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Safety mechanism assisted by the repressor of tetracycline (SMART) vaccinia virus vectors for vaccines and therapeutics. Grigg P, Titong A, Jones LA, et al. Proc. Natl. Acad. Sci. U. S. A. 110(38), 15407-12, (2013)

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Light-source-dependent role of nitrate and humic acid in tetracycline photolysis: kinetics and mechanism. Niu J, Li Y, and Wang W Chemosphere 92(11), 1423-9, (2013)

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3-O-phosphate ester conjugates of 17-?-O-{1-[2-carboxy-(2-hydroxy-4-methoxy-3-carboxamido)anilido]ethyl}1,3,5(10)-estratriene as novel bone-targeting agents. Shama Nasim et al Bioorg. Med. Chem. Lett. 20, 7450-3, (2010)

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Molecular epidemiology of telithromycin-resistant pneumococci in Finland. Merja Rantala et al Antimicrob. Agents Chemother. 51, 1885-7, (2007)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Synthesis and antibacterial activity of some novel chiral fluorophoric biscyclic macrocycles. Perumal Rajakumar et al Bioorg. Med. Chem. Lett. 17, 5270-3, (2007)

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In vitro activity of a new quinoline derivative, ER-2, against clinical isolates of Mycoplasma pneumoniae and Mycoplasma hominis. Shilpakala Sainath Rao et al Antimicrob. Agents Chemother. 53, 5317-8, (2009)

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Bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent. Jason R Neale et al Bioorg. Med. Chem. Lett. 19, 680-3, (2009)

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Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors. Yuefen Zhou et al Bioorg. Med. Chem. Lett. 18, 3369-75, (2008)

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Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Schwartz J, Holmuhamedov E, Zhang X, et al. Toxicol. Appl. Pharmacol. 273(1), 172-9, (2013)

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Analysis of Myc-induced histone modifications on target chromatin. Martinato F PLoS ONE 3(11), e3650, (2008)

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Newer tetracycline derivatives: synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase. Dharmarajan Sriram et al Bioorg. Med. Chem. Lett. 17, 2372-5, (2007)

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Efficient one-pot preparation of novel fused chromeno[2,3-d]pyrimidine and pyrano[2,3-d]pyrimidine derivatives. Hala M Aly et al Eur. J. Med. Chem. 47, 18-23, (2012)

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Green synthesis and antimicrobial evaluation of some new trifluoromethyl-substituted hexahydropyrimidines by grinding. Hussein F Zohdi et al Eur. J. Med. Chem. 46, 5636-40, (2011)

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Quantitative real-time PCR study of the expression and regulation of the tetracycline resistance gene in Riemerella anatipestifer. Zhong CY, Cheng AC, Wang MS, et al. Poult. Sci. 92(6), 1552-9, (2013)

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Aptamer based extraction followed by electrospray ionization-ion mobility spectrometry for analysis of tetracycline in biological fluids. Aslipashaki SN, Khayamian T, and Hashemian Z J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 925, 26-32, (2013)

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Occurrence and distribution of veterinary antibiotics and tetracycline resistance genes in farmland soils around swine feedlots in Fujian Province, China. Huang X, Liu C, Li K, et al. Environ. Sci. Pollut. Res. Int. 20(12), 9066-74, (2013)

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Technological and safety properties of lactic acid bacteria isolated from Spanish dry-cured sausages. Landeta G, Curiel JA, Carrascosa AV, et al. Meat Science 95(2), 272-80, (2013)

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Oral rabies vaccination variation in tetracycline biomarking among Ohio raccoons. Algeo TP, Norhenberg G, Hale R, et al. J. Wildl. Dis. 49(2), 332-7, (2013)

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Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus. Jian Lv et al Bioorg. Med. Chem. Lett. 17, 4102-6, (2007)

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Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. Betul Tekiner-Gulbas et al Eur. J. Med. Chem. 42, 1293-9, (2007)

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Conditional mutant mice using tetracycline-controlled gene expression system in the brain. Aiba A and Nakao H Neurosci. Res. 58(2), 113-7, (2007)

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Oral syphilis: a series of 5 cases. Hertel M, Matter D, Schmidt-Westhausen AM, et al. J. Oral Maxillofac. Surg. 72(2), 338-45, (2014)

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Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

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Prevalence of tetracycline resistance genes and identification of tet(M) in clinical isolates of Escherichia coli from sick ducks in China. Hu GZ, Pan YS, Wu H, et al. J. Med. Microbiol. 62(Pt 6), 851-8, (2013)

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Contemporary potencies of minocycline and tetracycline HCL tested against Gram-positive pathogens: SENTRY Program results using CLSI and EUCAST breakpoint criteria. Jones RN, Wilson ML, Weinstein MP, et al. Diagn. Microbiol. Infect. Dis. 75(4), 402-5, (2013)

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Anti-Helicobacter pylori and urease inhibition activities of some traditional medicinal plants. Amin M, Anwar F, Naz F, et al. Molecules 18(2), 2135-49, (2013)

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A simple, rapid and inexpensive screening method for the identification of Pythium insidiosum. Tondolo JS, Loreto ES, Denardi LB, et al. J. Microbiol. Methods 93(1), 52-4, (2013)

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Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice. Elzeinová F, Pěknicová J, Děd L, et al. Exp. Toxicol. Pathol. 65(6), 911-7, (2013)

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Transposon-mediated stable integration and tetracycline-inducible expression of electroporated transgenes in chicken embryos. Takahashi Y, Watanabe T, Nakagawa S, et al. Methods Cell Biol. 87, 271-80, (2008)

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Protein kinase Cδ stimulates proteasome-dependent degradation of C/EBPα during apoptosis induction of leukemic cells. Meng Zhao et al PLoS ONE 4, e6552, (2009)

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PhoR/PhoP two component regulatory system affects biocontrol capability of Bacillus subtilis NCD-2. Qinggang Guo et al Genet. Mol. Biol. 33, 333-40, (2010)

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Tigecyclin--the first glycylcycline to undergo clinical development: an overview of in vitro activity compared to tetracycline. Felmingham D J. Chemother. 17 Suppl 1, 5-11, (2005)

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Improved applications of the tetracycline-regulated gene depletion system. Nishijima H, Yasunari T, Nakayama T, et al. Biosci. Trends 3(5), 161-7, (2009)

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Enhancement of the photocatalytic activity of Ferrous Oxide by doping onto the nano-clinoptilolite particles towards photodegradation of tetracycline. Nezamzadeh-Ejhieh A and Shirzadi A Chemosphere 107, 136-44, (2014)

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Validation of otolith daily increments in early juveniles of shanny Lipophrys pholis. Carvalho MG, Moreira AS, Moreira C, et al. J. Fish Biol. 84(4), 1234-9, (2014)

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Molecular epidemiology of Neisseria gonorrhoeae isolates from Saskatchewan, Canada: utility of NG-MAST in predicting antimicrobial susceptibility regionally. Thakur SD, Levett PN, Horsman GB, et al. Sex. Transm. Infect. 90(4), 297-302, (2014)

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IgA pemphigus: case series with emphasis on therapeutic response. Moreno AC, Santi CG, Gabbi TV, et al. J. Am. Acad. Dermatol. 70(1), 200-1, (2014)

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[A tetracycline-inducible gene system allows for regulated production of proteins with therapeutic potential]. Castillo-Ureta H, Barrera-Saldaña HA, and Martínez-Rodríguez HG Rev. Invest. Clin. 56(6), 748-55, (2004)

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Merck 14,9196

Beil. 14,IV,2625

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