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T3301 Sigma

Transforming Growth Factor-β1 Receptor II Soluble Fragment human

≥97% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder

Synonym: TGF-β1 RII

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Description

Analysis Note

The receptor mediated activity of human TGF-β1 receptor II soluble fragment is measured by its ability to inhibit the TGF-β1 bioactivity in HT-2 cells.

Physical form

Lyophilized from 0.2 μm filtered phosphate buffered saline containing 1.25 mg bovine serum albumin

Application

Recombinant, human TGF-β1 sRII may be used to inhibit TGF-β1 activity on mouse T cell line, HT-2.

General description

Transforming growth factor-β (TGF-β) belongs to the TGF-β superfamily of secreted proteins. The TGF-β family is involved in a variety of signaling pathways that involve serine/threonine protein kinases. TGF-β acts through binding to three transmembrane receptors in mammals, type I, type II and type III receptors. It is expressed by most cell types and regulates the DNA-binding activity of transcription factors. The important pathways regulated by TGF-β are the SMAD, BMP, MAPK and PI3K/Akt pathways. TGF-β is involved in cell and tissue differentiation, proliferation, morphogenesis, secretion of metalloproteases and inflammation. Deregulation of TGF-β signaling has been implicated in many developmental syndromes and cancer progression
Recombinant, human TGF-β1 soluble receptor II will bind to TGF-β1, -β2, -β3, and -β5.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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