Tyrphostin AG 490 solid | Sigma-Aldrich

Properties

Related Categories	Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Jak-2 protein tyrosine kinase (PTK), Janus Kinase (JAK), Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, Phosphorylation Analysis, Post-Translational Modification, Protein Kinase Inhibitors, Proteomics, T, Tyrosine Kinase Inhibitors More...
form	solid
color	yellow
solubility	ethanol: soluble5 mg/mL
	H₂O: insoluble
storage temp.	−20°C
Gene Information	human ... EGFR(1956), ERBB2(2064), IL2(3558), JAK2(3717)

Description

Biochem/physiol Actions

Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.

Caution

Photosensitive

Price and Availability

Related Papers

Fyn and JAK2 mediate Ras activation by reactive oxygen species. Abe, et al. J. Biol. Chem. 274, 21003-21010, (1999)

Documents

Certificate of Analysis

Certificate of Origin

JAKs (166 KB )

Safety Information

Symbol	GHS06, GHS09
Signal word	Danger
Hazard statements	H301-H400
Precautionary statements	P273-P301 + P310
Hazard Codes (Europe)	T,N
Risk Statements (Europe)	25-50
Safety Statements (Europe)	45-61
WGK Germany	3