|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K,|
|solubility||ethanol: soluble5 mg/mL|
|Gene Information||human ... EGFR(1956), ERBB2(2064), IL2(3558), JAK2(3717)|
Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.
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Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase. Al-Shami, et al. J. Biol. Chem. 274, 5333, (1999)
Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Eriksen, K.W., et al. Leukemia 15, 787-793, (2001)
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