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T3535 Sigma

Calcitonin human

≥97% (HPLC), powder

Synonym: Calcitonin M, human C carcinoma, Calcitonin, human reduced cyclic (1→7)-disulfide, Thyrocalcitonin, hCT

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Description

Amino Acid Sequence

Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 [Disulfide Bridge: 1−7]

Biochem/physiol Actions

Hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes.

Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase.

Other Notes

32 amino acid polypeptide, 8 of which are conserved across all species.

Lyophilized from 0.1% TFA in H2O

Preparation Note

Calcitonin human dissolves in 1% acetic acid as well as in water at 1 mg/ml to yield a clear, colorless solution.

Application

Calcitonin human can be used as a positive control in in vivo study of HLA-A(*) 02.01 (HHD) mice injected with PTH-rP peptides.The product can also be used as a test compound for studying the effects of calcitonin deficiency and calcitonin substitution on particle-induced osteolysis in Calca -/- mice.

Price and Availability


Amplified Detection

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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