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T3652 Sigma

Triptolide

from Tripterygium wilfordii, ≥98% (HPLC), solid

Synonym: PG 490

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood,
biological source   from Tripterygium wilfordii
InChI Key   DFBIRQPKNDILPW-KTGKZQHOSA-N
assay   ≥98% (HPLC)
form   solid
color   white to off-white
solubility   DMSO: soluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNFα) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction.

Packaging

1, 5 mg in glass insert

Preparation Note

Triptolide is soluble in DMSO. The stock solution should be stored in DMSO at -20 deg C after reconstitution.

Application

Triptolide has been used as a NF-κB inhibitor to study the inhibition of cell invasion and angiogenesis in human thyroid cancer cells6. Triptolide has also been used to study its apoptotic effects in anaplastic thyroid cancer cells7.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
YK7751000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Immunology Research

The immune system is a complex network to detect and defend against non-self pathogenic agents, such as disease-causing viruses, bacteria, and other microorganisms. Various signaling pathways contrib...
Keywords: Antibiotics, Antifungals, Antivirals, Apoptosis, Bioactive small molecules, Cell signaling, Diabetes, Diseases, Immunology, Inflammation

Traditional Medicinals and Cancer

Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, Sigma® Life Science and Chloe McClanahan, Product Manager, Sigma Life Science
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Cancer, Drug discovery, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Nuclear magnetic resonance spectroscopy, Pharmaceutical

Peer-Reviewed Papers
15

References

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