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T4568 Sigma

Tyrphostin AG 528

~90%

Synonym: N-(3′,4′-Dihydroxybenzylidenecyanoacetyl)indoline, Tyrphostin B66

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
InChI Key   MYKCTDWWIWGLHW-NTEUORMPSA-N
assay   ~90%
potency   IC50 (2.1 micromolar, HER1-2 kinase activity)
  IC50 (4.9 micromolar for EGFK kinase activity)
solubility   DMSO: soluble10 mg/mL
storage temp.   −20°C
Gene Information   human ... EGFR(1956), ERBB2(2064)

Description

Biochem/physiol Actions

EGFR protein tyrosine kinase inhibitor.

Preparation Note

Tyrphostin AG 528 is soluble in DMSO at 10 mg/ml.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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