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T4680 Sigma

Terazosin hydrochloride

≥98% (TLC), powder

Synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride

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Properties

Related Categories Abbott, Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates,
InChI Key   IWSWDOUXSCRCKW-UHFFFAOYSA-N
assay   ≥98% (TLC)
form   powder
color   white to off-white
solubility   H2O: soluble19.60 - 20.40 mg/mL, clear, colorless to faintly yellow
  methanol: soluble20 mg/mL, clear, colorless
  ethanol: soluble4 mg/mL
originator   Abbott
Gene Information   human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

Biochem/physiol Actions

α1-adrenoceptor antagonist.

Packaging

250 mg in glass bottle

50 mg in poly bottle

Preparation Note

Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.

Application

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies5. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods6.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TK8044925
Protocols & Articles

Articles

Antihypertensive Agents

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions

Peer-Reviewed Papers
15

References

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