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T4692 Sigma

Anti-Transforming Growth Factor-β3 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-TGF-β3

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Cytokines, Chemokines, and Growth Factors for Stem Cell Biology, Antibodies against Cytokines/Growth Factors/Chemokines for Stem Cell Biology, Antibodies for Cell Biology,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
  indirect ELISA: suitable
  neutralization: suitable
  western blot: 0.1 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... TGFB3(7043)
biological source   goat
conjugate   unconjugated
Featured Industry   Research Pathology

Description

Immunogen

Recombinant chicken transforming growth factor-β3 (TGF-β3) expressed in Sf 21 cells.

General description

Transforming growth factor-β3 (TGF-β3) belongs to the TGF-β superfamily of secreted proteins. TGF-β3 has been implicated in the physiology of adult lung, brain and heart. The TGF-β family is involved in a variety of signaling pathways that involve serine/threonine protein kinases. TGF-β3 acts through binding to TGF-βR2 transmembrane receptor in mammals. The important pathways regulated by TGF-β3 are the Alk-5/SMAD, RhoA/Rho-kinase and MAPK pathways. TGF-β3 is involved in morphogenesis, development of palate, angiogenesis, induction of epithelial-mesenchymal transition Deregulation of TGF-β signaling has been implicated in many developmental syndromes and cancer progression
Anti-Transforming Growth Factor-b3 (TGF-β3) recognizes human and chicken TGF-β3. The antibody shows less than 25 % cross-reactivity with amphibian TGF-b5 and less than 10 % cross-reactivity with TGF-β1, TGF-β1.2, and TGF-β2. This antibody also shows less than 5 % cross-reactivity with recombinant human LAP (latency associated peptide, TGF-β1).

Physical form

Lyophilized from a 0.2 μm filtered solution of PBS with 5% trehalose.

Application

Anti- Transforming growth factor-β3 (TGF-β3) antibody may be used for immunoblotting at a working concentration of 0.1 μg/ml. For immunohistochemistry a working concentration of 5-15 μg/ml may be used. The antibody is suitable for neutralization reactions (ND50 is 0.01-0.05 μg/ml).

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