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T5077 Sigma

Tissue Factor Proteinase Inhibitor-II

recombinant, expressed in Nicotiana (tobacco), ≥97% (SDS-PAGE)

Synonym: TFPI-2

  • Empirical Formula (Hill Notation) C407H592N116O117S6

  • Molecular Weight 9174.15

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Properties

recombinant   expressed in Nicotiana (tobacco)
assay   ≥97% (SDS-PAGE)
storage temp.   −20°C

Description

Analysis Note

One mg will inhibit ≥1.3 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein.

General description

First Kunitz domain of TFPI-II containing a lysine residue at position 24

Preparation Note

Soluble in water (0.5mg/ml) and in aqueous buffers of low ionic strength

Unit Definition

One trypsin unit will produce a ΔA253 of 0.001 per min with BAEE as substrate at pH 7.6 at 25 °C; reaction volume 3.2 ml, 1 cm light path.

Biochem/physiol Actions

Protease inhibitor of metastasis and angiogenesis. Hypermethylation of the TFPI-2 gene causes transcriptional silencing in choriocarconoma cells. The TFPI-2 gene may be a candidate tumor suppressor gene.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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